Rhinovirus circulation patterns and age predilection of infection in children from 1997-2018

Document Type

Conference Proceeding

Publication Date

2-1-2024

Publication Title

J Allergy Clin Immunol

Abstract

Rationale: Of the 3 rhinovirus (RV) species, RV-A and RV-C most frequently cause illnesses, and RV-C is closely associated with childhood wheezing. The large number of RV types (> 160) presents a challenge for vaccine development. Little is known about RV type-specific age predilection. Methods: Multicenter data were pooled from 14 cohorts (n = 4344 patients aged 0-18, 10329 samples) including partial sequencing of nasal swab samples collected from 1997-2018. We identified RV of each species that were consistently most prevalent. Mean age of infection for each type was evaluated amongst the top circulating viruses (Tukey’s test). Results: The top 5 circulating RV-C types were: C2(4.8%), C11(4.7%), C6(4.0%), C43(3.7%), and C15(3.4%). The top 5 circulating RV-A types were: A78(5.4%), A12(4.4%), A101(4.4%), A21(3.6%), and A36(3.4%). The frequency of these predominant types remained highly stable over the study period. Types C2 and C40 showed the lowest mean ages of infection, 1.54 and 2.31 years respectively. RV types A12, A78, and A56 demonstrated the lowest mean age of infection among RV-A viruses, 1.9, 2.2 and 2.4 years, respectively. This age variation was statistically significant when compared against other commonly circulating RVs. Species of viruses with the lowest mean age of infection were observed to be closely related phylogenetically. Conclusions: We documented remarkable stability of predominant types of all 3 RV species over 20 years. and a lower mean age of infection for certain types. The close phylogenetic relationship between RV with the lowest mean age of infection suggests a possible biologic mechanism for their age-related infectivity patterns.

Volume

153

Issue

2

First Page

AB145

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