Trans Epidermal Water Loss Trajectories During the First 24 Months of Life in the CANOE Birth Cohort

Document Type

Conference Proceeding

Publication Date

2-1-2024

Publication Title

J Allergy Clin Immunol

Abstract

Rationale: Increased transepidermal water loss (TEWL) measures are associated with the expression of atopic dermatitis during infancy. However, how changes in TEWL are related to early life environmental exposures and the development of atopic dermatitis (AD) is not well understood. Methods: Childhood Allergy and the Neonatal Environment (CANOE) is a high-risk, multi-site birth cohort of 483 pregnant women and their infants. TEWL was measured at birth, 4, 12, 18 and 24 months from non-lesional sites. AD was defined as ever having a doctor’s diagnosis by age 12 months, per parental report. Latent class growth analysis (LCGA) was used to identify underlying classes of TEWL trajectories. Results: Three TEWL trajectories were observed over the first 24 months of life. Trajectory 1 had 333 (67.5%) children, trajectory 2 had 55 (11.2%) children and trajectory 3 had 105 (21.3%) children. Trajectory 1 had intermediate TEWL levels, while trajectory 2 had low TEWL levels over time, both of which were relatively stable over time. Trajectory 3 had high TEWL at birth that decreased over 24 months. Children whose perinatal TEWL was taken before the first bath were on average lower (p=0.022), but no association was observed with gestational age at birth (p=0.87). AD was associated with a lower TEWL at 24 months (p=0.027), but not after adjusted for site (p=0.27). Conclusions: In a preliminary analysis, three TEWL trajectories were observed over the first 24 months of life. Further work will determine how pre-, peri- and post-natal exposures, and AD severity associate with TEWL trajectory.

Volume

153

First Page

AB242

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