Association of Host CDHR3 rs6967330 Genotype with Rhinovirus Infections in Children from 1997-2018
Recommended Citation
Gao Y, Choi T, Devries M, Tetreault K, Gangnon R, Bacharier L, Busse W, Camargo C, Cohen R, DeMuri G, Fitzpatrick A, Gergen P, Grindle K, Gruchalla R, Hartert T, Hasegawa K, Khurana Hershey G, Holt P, Homil K, Jartti T, Kattan M, Kercsmar C, Kim H, Laing I, Le Souef P, Liu A, Mauger D, Pappas T, Lee K, Patel S. Association of Host CDHR3 rs6967330 Genotype with Rhinovirus Infections in Children from 1997-2018. J Allergy Clin Immunol 2025; 155(2):AB296.
Document Type
Conference Proceeding
Publication Date
2-1-2025
Publication Title
J Allergy Clin Immunol
Abstract
Rationale: The single-nucleotide polymorphism rs6967330 in the rhinovirus C (RV-C) receptor cadherin related family member 3 (CDHR3) gene is associated with increased CDHR3 expression on airway epithelial cells and risk of asthma in children. We hypothesize that RV-C types rarely found during childhood infection are more common in hosts with AA/AG risk CDHR3 genotypes compared to GG homozygotes due to increased receptor density mediating greater viral binding and entry. Methods: We pooled multicenter data from 6 cohorts with RV typing from partially sequenced nasal samples from 1997-2018 (n=2095 patients age 0-18, 6325 samples, 5515 with genotype). We compared the proportions of infections in AA/AG to GG participants for each RV type and performed linear regression analysis grouped by species (RV-A, RV-B, and RV-C). Pearson correlations were calculated to evaluate linear relationship. Results: Children with AA/AG genotypes had higher rates of RV-C infections compared to children with GG genotype (slope=1.17). This was not true for RV-A or RV-B infections (slope=0.791 and 0.864, respectively). Pearson correlations revealed similarly strong linear relationship for all 3 RV species (RV-A, RV-B, and RV-C) with overlapping 95% confidence intervals (r=0.86 [0.79,0.91], r=0.90 [0.80,0.95], and r=0.89 [0.82,0.93], respectively). Conclusions: We demonstrated that children carrying the rs6967330 risk allele (A) have more RV-C infections within our large multicenter population. Contrary to our hypothesis, the CDHR3 risk genotypes AA/AG increased infections with all RV-C types and not just the less common viruses. These findings suggest that increased receptor density on airway epithelial cells generally increases susceptibility to RV-C infection.
Volume
155
Issue
2
First Page
AB296
