EE238 Eosinophilic Esophagitis-Related Healthcare Resource Utilization: A Retrospective Cohort Study of US Health Insurance Claims Data

Document Type

Conference Proceeding

Publication Date

7-1-2025

Publication Title

Value Health

Keywords

adolescent, adult, aged, Caucasian, child, cohort analysis, conference abstract, controlled study, drug therapy, emergency ward, eosinophilic esophagitis, eosinophilic gastritis, female, follow up, food impaction, gastroenteritis, health insurance, hospitalization, human, longitudinal study, major clinical study, male, outpatient, retrospective study, subacute care, United States

Abstract

Objectives: To assess eosinophilic esophagitis (EoE)-related healthcare resource utilization (HCRU) among patients in the USA. Methods: This retrospective, longitudinal cohort study analyzedUShealth insurance data from the Inovalon closed claims (ICC) database and the 100% sample of MedicareFee-For-Service (MFFS) parts A/B/D claims and enrollment data (January 1, 2016-December 31, 2022). Eligible patients (≥11 years old) had ≥2 claims (≥30 days apart) for EoE in the index period (January 1, 2017-December 31, 2021 [index date=date of first claim for EoE]) and had continuous enrollment in medical and pharmacy benefits for ≥12 months before and after their index date (baseline and follow-up, respectively). Patients with a post-index diagnosis of eosinophilic gastritis/gastroenteritis were excluded. EoE-related hospitalizations and emergency department (ED), outpatient and post-acute care visits were assessed. Results: Data from 37,809 and 15,109 patients (ICC and MFFS, respectively) were analyzed. Mean (standard deviation) ages of patients (ICC and MFFS) were 38.1 (16.7) and 66.8 (13.2) years, respectively; >50% of patients were male (ICC and MFFS) and 90.3% were White (MFFS only). During 12-months of follow-up, EoE-related HCRU (proportion of patients with ≥1 visit and mean [standard error] number of visits/patient/month) from ICC was: hospitalizations, 1.6% and 0.02 (0.17); ED, 3.7% and 0.04 (0.24); ED-food impactions, 1.5% and 0.02 (0.13); outpatient physician office, 98.1% and 3.00 (4.40); and any other outpatient, 42.0% and 0.69 (1.12). Corresponding MFFS data were: hospitalizations, 2.7% and 0.03 (0.22); ED, 2.3% and 0.03 (0.18); ED-food impactions, 1.0% and 0.01 (0.10); outpatient physician office, 95.6% and 3.12 (2.53); and any other outpatient, 32.3% and 0.56 (1.08). Proportions of patients with ≥1 visit for post-acute care were ≤0.7% (ICC and MFFS). Conclusions: EoE represents a substantial healthcare burden in adolescents and adults in the USA, driven by frequent outpatient visits; food impactions were a leading cause of ED admissions.

Volume

28

Issue

6

First Page

S106

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