The Association of Daily Temperature and Humidity with Atopic Diseases in Early Childhood in a Multi-Center Birth Cohort
Recommended Citation
Koueik J, Ryan P, Sitarik A, Mandel S, Gern J, Hartert T, Johnson C, Rivera-Spoljaric K, Zoratti E, Gold D, Blossom J, Luttmann-Gibson H, Singh AM. The Association of Daily Temperature and Humidity with Atopic Diseases in Early Childhood in a Multi-Center Birth Cohort. J Allergy Clin Immunol 2026; 157(2):AB268.
Document Type
Conference Proceeding
Publication Date
2-10-2026
Publication Title
J Allergy Clin Immunol
Keywords
adult, age, allergic disease, atopic dermatitis, atopy, birth, birth cohort, childhood, chronic rhinitis, climate, cohort analysis, conference abstract, controlled study, female, human, humidity, infancy, major clinical study, male, rhinitis, skin water loss, special situation for pharmacovigilance, temperature, weather, wheezing
Abstract
Rationale: Weather elements can influence the development of atopic dermatitis (AD) and wheezing. We tested whether daily outdoor temperature and humidity associated with transepidermal water loss (TEWL) and allergic diseases during infancy. Methods: Participants were recruited from four centers (Madison, Detroit, St. Louis, Nashville) with distinct climates in the Childhood Allergies and NeOnatal Environment (CANOE) birth cohort. Birth addresses were geocoded to obtain daily outdoor temperature and humidity measurements during the first year of life. We tested whether average daily temperature and humidity over the first 6 months of life were associated with TEWL, AD, rhinitis and wheezing at age 1. Results: Increases in 1°C of mean temperature for the first 1 and 3 months were associated with a decreased risk of AD [n=287, OR (95% CI)=0.97 (0.94, 0.99), p=0.02; 0.95 (0.93, 0.98), p<0.01 respectively]. An increase in 1g/m3 of absolute humidity was associated with lower risk of AD during the first 1 ,3 and 6 months [n=287, OR (95% CI)=0.94 (0.89, 0.99), p=0.02; 0.91 (0.85, 0.97), p<0.01; OR (95% CI)=0.90 (0.82, 0.97), p<0.01 respectively] and wheezing during the first 1 and 3 months [n=212, OR (95% CI)=0.93 (0.87, 0.99), p=0.03; 0.92 (0.85, 0.99), p=0.03 respectively]. Temperature and humidity were not associated with TEWL [n=300, TEWL (95% CI)=-0.15 (-0.08, 0.00), p=0.05; -0.16 (-0.33, 0.02), p=0.08 respectively] or chronic rhinitis [n=269, OR (95% CI)=1.01 (0.99, 1.04), p=0.39; 1.02 (0,97 , 1.08), p=0.45 respectively]. Conclusions: Lower outdoor temperature and humidity were associated with increased risk of AD and/or wheezing during infancy in a prospective birth cohort.
Volume
157
Issue
2
First Page
AB268
