Allergic Sensitization Patterns Throughout Childhood in a US Birth Cohort: A Latent Transition Analysis

Authors

• Stephanie Latshaw, Henry Ford HealthFollow
• Alexandra Sitarik, Henry Ford HealthFollow
• Chun-Hui Lin, Henry Ford HealthFollow
• Andrea Cassidy, Henry Ford HealthFollow
• Amy Eapen, Henry Ford HealthFollow
• Haejin Kim, Henry Ford HealthFollow
• Alan Baptist, Henry Ford HealthFollow
• Christine Johnson, Henry Ford HealthFollow
• Edward Zoratti, Henry Ford HealthFollow

Recommended Citation

Latshaw S, Sitarik A, Lin C, Cassidy A, Eapen A, Kim H, Baptist A, Johnson C, Zoratti E. Allergic Sensitization Patterns Throughout Childhood in a US Birth Cohort: A Latent Transition Analysis. J Allergy Clin Immunol 2026; 157(2):AB96.

Document Type

Conference Proceeding

Publication Date

2-10-2026

Publication Title

J Allergy Clin Immunol

Keywords

allergen, immunoglobulin E, age, allergic disease, allergic rhinitis, asthma, atopic dermatitis, birth cohort, child, childhood, cohort analysis, conference abstract, controlled study, diagnosis, human, longitudinal study, milk, peanut, probability, sensitization

Abstract

Rationale: Age-specific allergen sensitization patterns may differentially associate with atopic dermatitis (AD) and other allergic conditions including asthma and allergic rhinitis (AR). Methods: Prospectively collected data from a southeast Michigan birth cohort was used to assess longitudinal allergen-specific IgE sensitization patterns. Sensitization patterns at age 2 years (n=589) and 10 years (n=554) were assessed for associations with AD, asthma, and AR. Latent transition analysis was then used to characterize shifting sensitization patterns between age 2 and 10 years. Results: Three latent sensitization patterns at age 2 included: low/no sensitization (LN), milk/egg dominant (ME), and highly sensitized groups (HS). Four patterns at age 10 included: LN, HS, perennial inhalant (PI), and seasonal inhalant with peanut (SIP). Compared to LN at age 2, ME and HS at age 2 were associated with higher odds ratios (OR) for AD at age 2 (ORME=3.22, (1.87, 5.55); ORHS=5.19 (1.96, 13.71) and AD at age 10 (ORME=4.18 (2.13, 8.19); ORHS=3.29 (1.05, 10.26). HS and ME classes at age 2 were significantly associated with increased odds of asthma and AR at 10 years. At age 10, HS, PI, and SIP were significantly associated with concurrent AD risk (ORSIP=6.80 (2.73, 16.93); ORPI=3.52 (2.01, 6.16); ORHS=5.07 (2.60, 9.90)), while HS and PI were significantly associated with concomitant asthma. Latent patterns indicating LN and HS at age 2 had high probability of persisting through age 10, while children with an ME pattern at age 2 had variable transition probabilities. Conclusions: Sensitization patterns throughout childhood change over time and are differentially associated with allergic outcomes.

Volume

157

Issue

2

First Page

AB96