Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity

Document Type

Article

Publication Date

10-1-2026

Publication Title

Interv Cardiol Clin

Keywords

Humans, Heart Valve Prosthesis, Transcatheter Aortic Valve Replacement, Aortic Valve, Multidetector Computed Tomography, Aortic Valve Stenosis, Bioprosthesis, Prosthesis Failure

Abstract

The expansion of transcatheter aortic valve replacement (TAVR) into younger and lower-risk populations has heightened attention toward long-term valve durability. Hypoattenuated leaflet thickening (HALT), a subclinical imaging finding identified on multidetector computed tomography, has emerged as a relatively common occurrence following TAVR. It is characterized by low-attenuation, often meniscal-shaped thickening of bioprosthetic valve leaflets and may be present with or without associated reduced leaflet motion. Although frequently asymptomatic, HALT is increasingly recognized as part of a broader spectrum of leaflet thrombosis that may progress to clinically significant valve dysfunction.

Medical Subject Headings

Humans; Heart Valve Prosthesis; Transcatheter Aortic Valve Replacement; Aortic Valve; Multidetector Computed Tomography; Aortic Valve Stenosis; Bioprosthesis; Prosthesis Failure

PubMed ID

42648865

Volume

15

Issue

4

First Page

637

Last Page

646

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