USE of OPTICAL COHERENCE TOMOGRAPHY and REFLECTANCE CONFOCAL MICROSCOPY to GUIDE TREATMENT MARGINS of BASAL CELL CARCINOMA
Recommended Citation
Wuennenberg J, Ozog DM, Kohli I, Jones B. USE of OPTICAL COHERENCE TOMOGRAPHY and REFLECTANCE CONFOCAL MICROSCOPY to GUIDE TREATMENT MARGINS of BASAL CELL CARCINOMA. Lasers Surg Med 2022; 54(SUPPL 34):S31-S32.
Document Type
Conference Proceeding
Publication Date
6-2-2022
Publication Title
Lasers Surg Med
Abstract
Background: Determining the clinical margins of basal cell carcinoma (BCC) is challenging. Noninvasive in vivo images of the skin created by optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) can aid in this endeavor. Interpreting OCT is challenging for the novice user which may result in benign lesions being interpreted as superficial BCC. The use of RCM with higher, near histologic, resolution relative to OCT can help detect the presence of BCC. Since RCM imaging is more time consuming for larger lesions relative to OCT, its utilization as a targeted approach in combination with OCT can be more efficient. Study Design/Materials and Method: Patients with biopsy-proven BCC had the initial treatment margins established by clinical exam and dermoscopy. Then OCT was used to scan the lesion centrally and at least four positions on the margins. RCM was performed at sites that were suspicious with OCT. The margin was adjusted based on the findings of the two imaging modalities. Results: BCC lesions of three subjects were treated following the OCT and RCM combined guidance. In two cases OCT revealed features that could be mistaken as BCC by novice users which upon further evaluation with RCM demonstrated diagnostic features of seborrheic keratosis. One case clearly showed BCC on OCT and the treatment margins were redrawn. This margin was confirmed with RCM. In a 4th case involving an 8×4cm recurrent BCC, 13 OCT scans were performed at the margin. RCM was performed at five locations that appeared suspicious for BCC. Conclusion: The use of clinical exam, dermoscopy, OCT, and RCM in a serial approach can enhance the physicians mapping of a tumors margins to ensure a more successful treatment.
Volume
54
Issue
SUPPL 34
First Page
S31
Last Page
S32
