0419 Exposure risk of sunburns in the development of keratinocyte carcinoma: A meta analysis

Document Type

Conference Proceeding

Publication Date

8-1-2025

Publication Title

J Invest Dermatol

Abstract

Ultraviolet exposure is an established risk factor for the development of keratinocyte carcinoma (KC) but quantitative synthesis of published reports is limited. The aim of this study is to evaluate the effect of sunburn exposure on the odds of KC development. PubMed and Embase databases were queried from the period of January 1964 to December of 2023 to identify potential studies for inclusion. Meta-analysis was used to estimate the increase in odds for patients who reported ever having a sunburn during the study period. A dose-response meta-analysis was used to evaluate the effect of an increasing number of sunburns on the odds of developing KC. Of the 35 studies that were included, 31 reported outcomes specific to basal cell carcinoma (BCC) and 15 reported outcomes specific to squamous cell carcinoma (SCC). A total of 1,070,698 persons were analyzed across all included studies. A history of sunburn was associated with an increased odds of BCC and SCC by 53% and 40% (BCC, OR: 1.53, n95% CI: 1.40-1.67, p <0.0001;SCC, OR: 1.40, 95% CI: 1.25-1.55, p <0.0001, ) respectively. Ever reported history of sunburn during lifetime (OR:1.60, 95% CI: 1.43-1.70, p = 0.0001), and during pediatric/adolescent periods (OR: 1.43, 95% CI: 1.21-1.69, p <0.0007) was associated with significantly increased odds of BCC and SCC respectively. Each additional sunburn per year increased the odds of developing BCC by 57% (OR: 1.57, 95% CI: 1.40-1.77, p value <0.0001) and SCC by 44% (OR: 1.44, 95% CI: 1.24-1.66, p value <0.0001). As a retrospective study, limitations include recall bias and confounding factors such as differences in skin phototype of participants. Furthermore, subgroup analysis was limited by a low number of studies. In conclusion, the odds of BCC and SCC are increased by sunburn exposure and the odds increase per sunburn for most of the periods of life that were studied.

Volume

145

Issue

8

First Page

S72

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