Pigmentation and Oxidative Biomarker Modulation across All Skin Types (Fst I-Vi) Following Exposure to Boundary Region Wavelengths (Longest Ultraviolet a Plus High Energy Visible Light): A Controlled Clinical Study
Recommended Citation
Moses S, Shyr T, Meyer K, Daly S, Williams JD, Kohli I, Mohammad T, Lim H. Pigmentation and Oxidative Biomarker Modulation across All Skin Types (Fst I-Vi) Following Exposure to Boundary Region Wavelengths (Longest Ultraviolet a Plus High Energy Visible Light): A Controlled Clinical Study. J Am Acad Dermatol 2026; 95(1):AB341.
Document Type
Conference Proceeding
Publication Date
7-1-2026
Publication Title
J Am Acad Dermatol
Keywords
Dermatology
Abstract
Current UV filters provide absorbance predominantly in the range of 290-380nm which enable protection against sunburn, photocarcinogenesis, hyperpigmentation and photoaging changes. This study evaluated the cutaneous effects of Longest Ultraviolet A(LUVA), 380-400nm, and LUVA + High Energy Visible Light (HEVL), 380-420nm (Boundary Region Light) on 18 female subjects, n=3 per Fitzpatrick Skin Type(FST) I-VI. Pigmentation was assessed using Investigator’s Global Assessment (IGA), chromametry and image analysis. Additionally, catalase activity (U/mg proteins) was measured using a fluorescence assay and malondialdehyde (MDA) concentrations (ng/mg proteins) were measured using GC/MS as biomarkers of cutaneous oxidative stress. Results: demonstrated that all subjects responded to both light regimens by developing immediate and persistent skin pigmentation (IGA). All FST’s had dose dependent increase in pigmentation (↓ITA) while FST I/II had a dose dependent increase in redness (↑a*). Immediate pigment darkening (IPD) at 15 minutes and persistent pigment darkening (PPD) at 24 hours were strongest in FST IV requiring the lowest minimum mean energy dose to induce, 3.63J/cm2 for IPD and 15.31J/cm2 for PPD with Boundary Region Light. Mean oxidative stress biomarkers were significantly changed with decrease in catalase activity and increase in MDA concentration at higher doses across all skin types (n=18) for both light regimens. Most significant changes in biomarkers occurred at the highest doses in the FST I subpopulation (n=3) as compared to non-irradiated control. Hyperpigmentation and oxidative stress in all skin types following boundary region light exposure was established. This will enable evaluation of protection beyond the 290-380nm spectrum in future studies.
Volume
95
Issue
1
First Page
AB341
