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Henry Ford Hospital Medical Journal

Abstract

A 60-year-old woman developed high fever, jaundice, anemia with pancytopenia and hepatosplenomegaly. She deteriorated rapidly and died one month later, having shown no beneficial effect from high dose corticosteroids and splenectomy. An antemortem diagnosis of malignant histiocytosis of the Robb-Smith type was made and duly confirmed by autopsy study. This rare disorder of the reticuloendothelial system, heretofore designated "histiocytic medullary reticulosis," deserves recognition and inclusion among the histiocytic diseases and in the classification of the lymphomas. Its proper nosologic designation is suggested.

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