Weakness purpura mixed arthralgia cryoglobinemia (IgG - IgM) syndrome was first described by Meltzer in 1966. Such a case was recently reported after treatment with Cyclophosphamide and subsequent splenectomy for pancytopenia with beneficial effects on the cryocrit. The patient reported here underwent splenectomy without Cyclophosphamide and had subsequent amelioration of the clinical symptoms. Abnormal plasma cells found in the spleen presumably were responsible (at least in part) for the patient's symptomatology.
Haeger, Carl R.
"Purpura Arthralgia Weakness Mixed Cryoglobulinemia Syndrome Treated with Splenectomy: A Case Report,"
Henry Ford Hospital Medical Journal
: Vol. 21
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol21/iss1/3