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Henry Ford Hospital Medical Journal

Abstract

Our method for evaluating the surface response of any given platelet population, which has evolved over the past two decades, provides a measure of both the adhesive and cohesive qualities of platelets. General morphologic features of the adherent, whole platelets can be assessed by transmission electron microscopy, and the results are reproducible when serial samples are collected on normal subjects and patient groups. With this technique, different metabolites and drugs can be combined with platelet populations that are either normoresponsive or hyperactive to determine if these substances trigger or inhibit the platelet response. To date, the results from in vitro studies have paralleled in vivo findings during clinical trials. The method appears suitable for assessing the degree of surface response for any platelet population, determining the in vitro action of a variety of substances on the platelet response, and for monitoring the antiplatelet capacity of established as well as experimental therapeutic agents.

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