Henry Ford Hospital Medical Journal


The presence of giant organelles in the cytoplasm of peripheral blood elements is diagnostic for the Chediak-Higashi syndrome. These abnormal cytoplasmic inclusions are found within neutrophils, eosinophils, basophils, lymphocytes, monocytes, and platelets. Their fine structural characteristics differ. Neutrophils demonstrate striking variability in the size, shape, and internal features of their giant organelles. Lymphocytes contain two different types of giant inclusions, one with a smoothly homogeneous substructure, the other with structures resembling microtubules. Emphasizing the ultrastructural similarities and differences of these anomalous granulations may provide valuable clues for understanding the basic defect of this inherited disorder.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.