Henry Ford Hospital Medical Journal


A clinical trial is currently in progress to determine the efficacy of combined fractions of hyperthermia and radiation. The protocol consists of two parts. First, four fractions of microwave-induced hyperthermia (45.0° ± 0.5°C) are applied for 1 1/2 hours to the volume encompassing the tumor, each separated by 72 hours. After a one-week rest, a second series of four fractions is administered again at 72- hour intervals. Each fraction consists of a 400 rad dose of radiation followed within 20 minutes by hyperthermia (42.5 ± 0.5°C) for 1 1/2 hours. Currently, we have treated 62 patients with 82 fields with a mean follow-up time of six months to date. Total regression was observed in 60% of all cases, and partial regression in 33%; no response was seen in only 6% of all those treated. Five local and three marginal recurrences have been observed. This paper discusses details of response based on site, histology, and classification.