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Henry Ford Hospital Medical Journal

Abstract

We measured levels of glycolytic metabolites in mouse tumor and liver after administering a glucose load of 6 mg/g of body weight and after hyperthermia for one hour at 43°C. Metabolites included glucose, glucose-6-phosphate, fructose-1.6-diphosphate, dihydroxyacetone-phosphate, glycerol-3-phosphate, pyruvate, and lactate, as well as acetoacetate and β-hydroxybutyrate. The combined treatment led to an increase of the lactate level and apparently enhanced glucose degradation. The redoxequilibria states were shifted to the reduced metabolites. It is possible that hypoxia was induced or enhanced, which could have significance for tumor therapy. At later periods after hyperthermia, metabolic alterations occurred that have also been observed in severe diabetes. These alterations occurred in the liver as well. In both situations, such alterations must be considered in connection with potential damage to normal tissue from hyperthermia.

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