Early Detection of Hereditary Medullary Thyroid Cancer with Polymorphic DNA Probes

Authors

Steven A. Narod
Hagay Sobol
Isabelle Schuffenecker
R. Alan B. Ezekowitz
Gilbert M. Lenoir

Abstract

We have performed linkage analysis on 32 families with hereditary medullary thyroid cancer (MTC) wilh seven polymorphic DNA probes situated near the centromere of chromosome 10. Nineteen of these families were affected with multiple endocrine neoplasia type 2A (MEN 2A), and the remainder had MTC without pheochromocytoma. There were no instances of recombination between the MEN 2 A susceptibility gene and the IRBP.H4 marker. Two other probes, TBM.34 and MCK2, are also tightly linked(θ = 0.00 and θ = 0.02. respectively). Because TBM.34 and IRBP.H4/MCK2 are situated on opposite sides of the MEN 2A gene, screening with flanking DNA markers is now feasible.

Recommended Citation

Narod, Steven A.; Sobol, Hagay; Schuffenecker, Isabelle; Ezekowitz, R. Alan B.; and Lenoir, Gilbert M. (1989) "Early Detection of Hereditary Medullary Thyroid Cancer with Polymorphic DNA Probes," Henry Ford Hospital Medical Journal : Vol. 37 : No. 3 , 106-108.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol37/iss3/5