Submissions from 2022
Polyamine Biomarkers of Parkinson's Disease Progression, Peter A. LeWitt, L. Hong, and R. Patil
Global Metabolomic Profiling of PSP and Healthy Controls Yields CSF and Serum Biomarkers, Peter A. LeWitt, L. VandeVrede, A. Boxer, and Jia Li
Deuterium-Stabilized (R)-Pioglitazone, PXL065, for Treatment of X-Linked Adrenoleukodystrophy (ALD), P. Monternier, Jaspreet Singh, S. DeWitt, P. Gluais, D. E. Moller, and S. Hallakou-Bozec
Predicting Disease Progression in Multiple Sclerosis by using a Combination of Highly Sensitive Single Molecule Array Technology (SIMOA) and Untargeted Metabolomics, Insha Zahoor, Jeffrey Waters, Indrani Datta, Mirela Cerghet, Laila M. Poisson, Ramandeep Rattan, and Shailendra Giri
Submissions from 2021
What role do urgent care centers play in headache management? A quality improvement study of select urgent care facilities, Annika Ehrlich, Dennique Khanns, Jenny Guiracocha, Fawad Khan, Ashhar Ali, Addie Peretz, Larry Charleston, Marius Birlea, Niranjan Singh, and Mia Minen
OPTI-on: A longitudinal real-world study of opicapone in patients with parkinson's disease and motor fluctuations, Peter A. LeWitt, O Klepitskaya, L B. Bahroo, G S. Liang, S Rattana, J Trotter, and M Serbin
Validation of direct AMP kinase (AMPK) activation for treatment of X-linked Adrenoleukodystrophy, P A. Monternier, Jaspreet Singh, P Gluais, D Moller, and S Bozec
Symptomatic Extracranial Carotid Disease in COVID-19 Patients Is Related to Thrombus Formation, Timothy Nypaver, Daniel J. Miller, Mitchell R. Weaver, Horia Marin, Alice Lee, Brent Griffith, Dee Dee Wang, and Loay S. Kabbani
Rhinologist referral to a headache specialist for non-sinogenic headache: A fast track approach to an interdisciplinary collaboration, Jaspreet Singh and Ashhar Ali
Mir-17-92 cluster-enriched exosomes improve tissue and functional recovery in rats after traumatic brain injury, Yanlu Zhang, Yi Zhang, Michael Chopp, Haiyan Pang, Zhenggang Zhang, Asim Mahmood, and Ye Xiong
Submissions from 2020
Cardioembolic stroke caused by bi-atrial thrombus and treated with intracardiac thrombectomy; a case report, Hisham Alhajala, Iyad Isseh, and Daniel Miller
Clinical, diagnostic and therapeutic spectrum of seropositive and seronegative autoimmune encephalitis: Single center cohort study of 51 cases, Lara Fahmy, Muhammad Affan, Anza B. Memon, and Mirela Cerghet
Safety and Efficacy of Continuous Apomorphine Infusion in Patients with Parkinson's disease: Results from a Phase 3, Open-label Study, Stuart Isaacson, Alberto Espay, Rajesh Pahwa, Thomas Clinch, and Peter A. LeWitt
Efficacy of Opicapone at Different Levodopa Regimens up to a Threshold of 600mg/Day Levodopa in Parkinson's Disease Patients with Motor Fluctuations, Peter A. LeWitt, Fabrizio Stocchi, Joaquim J. Ferreira, Olga Klepitskaya, Diogo Magalhaes, Jose-Francisco Rocha, and Patricio Soares-da-Silva
Efficacy and safety of fingolimod and dimethyl fumarate for management of multiple sclerosis: A single center retrospective study, Anza B. Memon, Lara Fahmy, Janet Kandrevas, and Mirela Cerghet
Clinical spectrum of stiff person syndrome associated with glutamic acid decarboxylase antibodies, Anza B. Memon, Anirudha S. Rathnam, Iram Zaman, and Naganand Sripathi
Atrio-Esophageal Fistula Associated with Stroke: 2 Case Reports Of Rare But Fatal Complication, Ghada Mohamed, Hassan A. Nour, and Panayiotis N. Varelas
Foix-Alajouanine Syndrome Mimicking Longitudinally Extensive Transverse Myelitis, Anirudha S. Rathnam, Iram Zaman, and Anza B. Memon
Calorie restriction for ovarian cancer reduction, Ramandeep Rattan, Irina Dimitrova, Mary P. Udumula, Thomas E. Buekers, and Shailendra Giri
MRI findings in Neurosarcoidosis Patients with Headache as a Primary Presenting Symptom, Yamin Sallowm, Muhammad Affan, Mirela Cerghet, and Ashhar Ali
Reversible cerebral vasoconstriction syndrome presenting with symptoms of intracranial hypotension, Jaspreet Singh and Ashhar Ali
The Headache That Broke My Heart: Cluster and Bradycardia, Jyotika Singh and Ashhar Ali
Central Nervous System/Vestibular abnormalities in Oculo-Auriculo-Vertebral Spectrum Disorders, Jyotika Singh and Jules Constantinou
Neuropathic Otalgia: Rare and Treatable Ear Pains, Aarushi Suneja, S Madani, and Ashhar Ali
Adult-onset CNS Langerhans Cell Histiocytosis: Mystery Cases, Aarushi Suneja, Anza B. Memon, and Abir Mukherjee
Coining the Pablo Picasso Syndrome, Ritika Suri and Ashhar Ali
Utility of Continuous Video EEG in patients with Cardiac Arrest, Ritika Suri, Lonni Schultz, Gregory L. Barkley, Jules Constantinou, Shaila Gaddam, Marianna Spanaki-Varelas, and Vibhangini S. Wasade
High Prevalence of Transthyretin-Related Amyloidosis in Crete, Greece is Due to Three TTR Pathogenic Variants with Markedly Differing Phenotypic Presentations, Minas Tzagournissakis, Emanouil Foukarakis, Anastasios Marinis, Lambros Mathioudakis, Kleita Michaelidou, Cleanthe Spanaki, Miltiadis Tsilimbaris, Andreas Plaitakis, Panayiotis Mitsias, and Ioannis Zaganas
Omega-3 lipid metabolites as mediators of metformin's anti-proliferative effect in ovarian cancer, Mary P. Udumula, Irina Dimitrova, S Sakr, Thomas E. Buekers, Shailendra Giri, and Ramandeep Rattan
Outcomes and Correlations Between Legacy Quality of Life Measures (EORTC-C30/EORTC-BN20) and the Electronic Quality of Life Measuring System (NIH PROMIS) in Glioblastoma Patients, Tobias Walbert, Lonni Schultz, and Aarushi Suneja
Submissions from 2019
Brainstem Modulation Therapy for the Management of Parkinson's Disease: Results from a Single-Site Randomized Controlled Trial, K Ade, D Wilkinson, A Podlewska, S E. Banducci, T Pellat-Higgins, M Bodani, M Sakel, L Smith, and Peter A. LeWitt
Novel Iron-Targeted Therapy Is Highly Effective in Treatment-Resistant High-Grade Glioma in Vivo, M Al-Gizawiy, R Wujek, M Prah, J Knipstein, Hisham Alhajala, N Doan, S Molino, S Mirza, C Chitambar, and K Schmainda
Is there a role for magnetoencephalography in pre-surgical RNS implantation in drug-resistant temporal lobe epilepsy?, Abdullah Alshammaa, R Keating, N Baki, A Mahajan, Gregory L. Barkley, A Zillgitt, and Susan M. Bowyer
Does non-automated phone call notification improve no-show rates in neurology resident clinic?, Abdullah Alshammaa, K Shah, S Madani, Muhammad Affan, S Zahoor, N Baki, A Yousuf, Lonni Schultz, Iram Zaman, and Tobias Walbert
Iv thrombolysis for stroke due to cervicocephalic arterial dissection: What is the right practice?, Owais Alsrouji, Muhammad Affan, and Panayiotis Mitsias
General Characteristics of Edaravone Use in the Natural History of ALS and Other Motor Neuron Disorders Consortium Dataset (NeuroBANK™), Ximena Arcila-Londono, D Walk, S Vota, A Sherman, K Goslin, G Hayat, C Lunetta, Daniel S. Newman, Kara Steijlen, J Wymer, N Olney, M Somers, H Yu, L Alvarado, J Jones, P Velpuri, K Faulconer, C Tarlanini, F Gerardi, and E Macklin
Bilateral horizontal gaze paralysis-case series, Poonam Bansal
Identification of distinct metabolic fingerprint of EAE disease discriminating from the healthy control using urine and plasma metabolomics, Mirela Cerghet, Laila M. Poisson, Jaspreet Singh, Indrani Datta, Hamid Suhail, Ramandeep Rattan, and Shailendra Giri
Cerebrolysin Ameliorates BBB Leakage and Microvascular Inflammation Induced by tPA and Fibrin, Michael Chopp, Chao Li, Hua Teng, Li Zhang, and Zheng Gang Zhang
The prognostic value of quantitative EEG in patients undergoing mechanical thrombectomy for acute ischemic stroke, A Dickey, W Olango, M Agan, W Roche, Panayiotis Mitsias, M Frankel, J Ratcliff, G Rodrigues, R Nogueira, D Haussen, and I K. Kis
Dendritic Remodeling of the Spinal Motor Neurons in the Denervated Gray Matter After Stroke in Mice, X Gan, Michael Chopp, J Fang, L He, and Zhongwu Liu
Validation of a new functional dyspnea score in amyotrophic lateral sclerosis: ALS functional dyspnea score, T Heiman-Patterson, C Jackson, M Sherman, J Shefner, Daniel S. Newman, S Scelsa, A Verma, Y Rollins, and E Kasarskis
Childbearing and parenthood during residency and fellowship, Khadija Irshad, D Dharaiya, and Iram Zaman
Racial disparities in moyamoya disease in a North American cohort, Khadija Irshad, Shaneela Malik, and Lonni Schultz
A Pooled Analysis for 8 Randomized Controlled Trials of Istradefylline, an Adenosine A2A Receptor Antagonist: Efficacy as Adjunct to Levodopa in Parkinson's Disease (PD), S H. Isaacson, N Hattori, M Onofrj, A Mori, K Toyama, P M. Salzman, E Ohta, and Peter A. LeWitt
Proteomic exosome evaluation in patients with sepsis and septic shock compared to healthy controls, Anja K. Jaehne, Wing Lee Cheung, Yalei Chen, Laila M. Poisson, Michael Chopp, Zhenggang Zhang, Benjamin Buller, Omokayode Osobamiro, Emanuel Rivers, and Daniel C. Morris
Extracellular vesicle size in early sepsis, Anja K. Jaehne, William Golembieski, Amy Kemper, Omokayode Osobamiro, Wing L. Cheung, Benjamin Buller, Zhenggang Zhang, Michael Chopp, Emanuel P. Rivers, and Daniel C. Morris
The Diagnostic Utility of ICH-Score in Patients with Anticoagulant Related Intracerebral Hemorrhage, P A. Katsanos, C Krogias, V A. Lioutas, N Goyal, R Zand, V Sharma, Panayiotis N. Varelas, Kiwon Malhotra, M Paciaroni, A Sharaf, J Chang, T Karapanayiotides, O Kargiotis, A Pappa, J Mai, A Tsantes, Panayiotis D. Mitsias, M Selim, A Alexandrov, and G Tsivgoulis
Unusual Presentations for Lupus: From Occular Oddities to Cauda Equina Nerve Root Enhancement, M S. Khan and Anza B. Memon
It's on the Tip of My Tongue! Prolonged Paresthesia of the Tongue After Dental Procedure, M S. Khan and Iram Zaman
Do Sleep Scales Correlate with Pulmonary Function in ALS? Results from the ALS Nutrition/NIPPV Study Group, O Khazaal, T Heiman-Patterson, M Sherman, C Jackson, Y Rollins, A Verma, J Shefner, S Scelsa, Daniel S. Newman, M Mendiondo, and E Kasarskis
Baseline IL-6 Levels Are Associated with Midline Shift and Functional Outcome in Spontaneous Intracerebral Hemorrhage: An Exploratoryanalysis of the Fast Trial, A Leasure, L Kuohn, Z King, M Bevers, W T. Kimberly, F D. Shi, Stephan A. Mayer, T Steiner, L Sansing, G Falcone, and K Sheth
Once-Daily Opicapone Increases ON-Time in Patients with Parkinson's Disease: Results from Two Phase 3 Studies, Peter A. LeWitt, D O. Claassen, K Olson, K Farahmand, S Siegert, M Alrais, J F. Rocha, P Soares-Da-Silva, and G S. Liang
Inhaled Levodopa (CVT-301) for Treatment of off Periods in Parkinson's Disease: Efficacy as Assessed by 39-Item Parkinson's Disease Quality of Life (QoL) Questionnaire, Peter A. LeWitt, R A. Hauser, C Oh, J Qian, C Kenney, and I Abeynayake
Cerebral Microbleed Prevalence and Burden in NOAC vs VKA-Associated Intracerebral Hemorrhage, V A. Lioutas, N Goyal, A Katsanos, C Krogias, R Zand, V Sharma, Panayiotis N. Varelas, K Malhotra, M Paciaroni, A Sharaf, J Chang, O Kargiotis, A Pandhi, C Schroeder, A Tsantes, Chandan Mehta, Panayiotis D. Mitsias, M Selim, A Alexandrov, and G Tsivgoulis
Comprehensive proteomics and microRNA analyses of adult neural stem cell derived exosomes after stroke, Xian-Shuang Liu, Michael Chopp, Chao Li, Wan-Long Pan, Baoyan Fan, Albert M. Levin, Ruilan Zhang, and Zhenggang Zhang
Overexpression of miR-133B in reactive astrocytes enhances their released exosomes which contribute to neurite remodeling and functional recovery after stroke, Zhongwu Liu, Michael Chopp, Yanfeng Li, X Gan, Fengjie Wang, Xia Shang, and Hongqi Xin
Overexpression of TPA in the spinal cord promotes corticospinal axonal remodeling and motor behavioral recovery in mice after stroke, Zhongwu Liu, Hongqi Xin, X Gan, Xia Shang, Fengjie Wang, Mei Lu, and Michael Chopp
Immune-Response Contributes to Primary Cardiac Dysfunction After Intracerebral Hemorrhage, Wei Li, T Yan, Lian Li, Poornima Venkat, Michael Chopp, Zhili Chen, Julie Landschoot-Ward, and Jieli Chen
Pharmacokinetics of Opicapone and Effect on Comt and Levodopa Pharmacokinetics in Patients with Parkinson's Disease, G Loewen, Peter A. LeWitt, C W. Olanow, K D. Kieburtz, G S. Liang, R Jimenez, K Olson, and E Roberts
Bilateral Optic Neuropathy as Initial Manifestation of Meningeal Carcinomatosis in Non-Small-Cell Lung Cancer, V Mastorodimos, A Mala, M Tsilimbaris, E Papadaki, and Panayiotis Mitsias
"CTA for All": Emergency CT Angiography for All Stroke Patients Presenting Within 24 Hours of Onset Improves Outcome After Large Vessel Occlusion, Stephan A. Mayer, Tanuwong Viarasilpa, Nicha Panyavachiraporn, Brent Griffith, Daniel J. Miller, Megan Brady, Dawn Scozzarri, Angelos Katramados, Hebah Hefzy, Shaneela Malik, Horia Marin, Max Kole, Alex B. Chebl, Christopher A. Lewandowski, and Panayiotis Mitsias
Characteristics of patients intubated for psychogenic non-epileptic seizures, Stephan A. Mayer, Tanuwong Viarasilpa, Nicha Panyavachiraporn, Gamaledin Osman, Panayiotis N. Varelas, and Noel O. Akioyamen
Treatment of obstructive sleep apnea with positive airway pressure to improve cognitive function in mild cognitive impairment, Beth McLellan, Virginia Skiba, Marina Novikova, Lonni R. Schultz, and Aarushi Suneja
Recurrent Thrombectomy in Patients with Prior Mechanical Endovascular Revascularization: A Single Center Experience, G A. Mohamed, K Arshad, Muhammad Affan, Owais Alsrouji, Daniel J. Miller, Max Kole, and Horia Marin
Floating heads: An Occi-dental discovery of bálint syndrome, Anirudha S. Rathnam, Muhammad Affan, and Daniel J. Miller
Implementation of standard note templates captures true level of service (LOS) coding, K Shah, Abdullah Alshammaa, Meredith Van Harn, Muhammad Affan, Daniel S. Newman, Gregory L. Barkley, Amy Pappas, and Daniel J. Miller
Does Administration of IV Contrast Impact Outcomes on Acute Ischemic Stroke Patients? A Propensity Score Matched Single Center Study, Kavit Shah, Stephan A. Mayer, Meredith G. Van Harn, Mohammed Ismail, Lonni Schultz, Horia Marin, Max Kole, and Daniel J. Miller
Therapeutic effects of D4F, an ApoA-I mimetic peptide, in aged mice subjected to ischemic stroke, Yulei Shen, Alex Zacharek, Poornima Venkat, Michael Chopp, Fengjie Wang, Julie Landschoot-Ward, Quan Jiang, and Jieli Chen
Clinical Characteristics, Diagnostic and Outcome Differences in Patients with Optic Neuritis, D Siegel, Meredith Van Harn, R Wenner, Poonam Bansal, Mirela Cerghet, and Anza B. Memon
Underestimation of ischemic core on perfusion CT in patients with acute large vessel occlusion: Results from the best prospective cohort study, J Siegler, S Messe, H Sucharew, T Mehta, N Arora, A Starosciak, F De Los Rios La Rosa, N Barnhill, A Mistry, K Patel, Salman Assad, A Tarboosh, K Dakay, J Wagner, A Bennett, B Jagadeesan, C Streib, S Weber, R Chitale, J Volpi, Stephan A. Mayer, S Yaghi, M Jayaraman, P Khatri, and E Mistry
Integration of Micrornaome and Metabolomics to Dissect Cerebral Disease Progression in X-Linked Adrenoleukodystrophy, Jaspreet Singh, Laila M. Poisson, and Shailendra Giri
Integrative metabolomics and transcriptomics analysis reveals a Krebs cycle metabolite “itaconate” in promoting inflammation resolution in bacterial endophthalmitis, S Singh, P K. Singh, Shailendra Giri, and A Kumar
Persistent neurological deficits in a patient with hemiplegic migraine revealing diffuse astrocytoma, Aarushi Suneja and A Ashhar
Brain-Heart Interaction After Stroke: Therapeutic Effects of Exosomes in Type 2 Diabetic Mice Subjected to Stroke, Poornima Venkat, C Cui, Jiang Xu, Alex Zacharek, Xiao-Ping Yang, Michael Chopp, Fengjie Wang, J L. Choot-Ward, and Jieli Chen
ApoA-I mimetic peptide reduces vascular and white matter damage after stroke in type 2 diabetic mice, Xinli Wang, Rongwen Li, Alex Zacharek, Julie Landschoot-Ward, Michael Chopp, Jieli Chen, and Xu Cui
MIR-17-92 cluster enriched msc exosomes promote myelination and axonal extension which contribute to increased EMG conduction and functional recovery after stroke in rats, Hongqi Xin, Zhongwu Liu, Benjamin Buller, Yanfeng Li, William Golembieski, X Gan, Fengjie Wang, Xia Shang, Zhenggang Zhang, and Michael Chopp
A Prospective, Randomized, Blinded, and Placebo-Controlled Study of Cerebrolysin Effect on Long-Term Functional and Histological Outcomes in Rats with Traumatic Brain Injury, Ye Xiong, Yi Zhang, Zheng Gang Zhang, Yanlu Zhang, Li Zhang, Mei Lu, Talan Zhang, H Wu, S Winter, E Doppler, H Brandstaetter, Asim Mahmood, and Michael Chopp
Sildenafil treatment of vascular dementia in aged rats, Alex Zacharek, Poornima Venkat, Michael Chopp, Julie Landschoot-Ward, and Jieli Chen
Exosomes derived from ischemic cerebral endothelial cells promote axonal growth, Yi Zhang, Michael Chopp, Chao Li, Xian-Shuang Liu, Xinli Wang, Li Zhang, and Zhenggang Zhang
Exosomes from cerebral endothelial cells suppress chemotherapyinduced peripheral neuropathy and sensitize anti-tumour effects of platinum drugs, Yi Zhang, Zheng Gang Zhang, Michael Chopp, and Chao Li
Exosome Treatment Improves Functional Recovery After Traumatic Brain Injury in Rats: A Dose-Response and Therapeutic Window Study, Yi Zhang, Yanlu Zhang, Michael Chopp, Mei Lu, Zheng Gang Zhang, Asim Mahmood, and Ye Xiong
Submissions from 2018
Clinical presentation and treatment of autoimmune encephalitis: Single center cohort study of 47 cases, Muhammad Affan, Sarah Madani, Gamaledin Osman, Owais Alsrouji, Lonni Schultz, and Mirela Cerghet
Left atrial dilatation: A cohort analysis with strong implications for future atrial fibrillation and stroke monitoring, Muhammad Affan, Sumul Modi, Lonni R. Schultz, Abhimanyu Mahajan, and Daniel Miller
Left atrial dilatation: A cohort analysis with strong implications for future atrial fibrillation and stroke monitoring, Muhammad Affan, Sumul Modi, Tom Smoot, Lonni Schultz, Abhimanyu Mahajan, and Daniel Miller
Unusual presentation of a large epidermoid tumor in a chronic migraine patient: Case report, Ayesha Ahmad and Ashhar Ali
New daily persistent headache (NDPH) & onabotulinumtoxina therapy, Ashhar Ali, Jennifer Kriegler, Stewart Tepper, and Brinder Vij
Erythromelalgia secondary to verapamil, Ashhar Ali and A Rothner
Single or dual brain death exams: Tertiary hospital experience over 11.5 years, Paul Brady, Mohammed Kananeh, Lisa Louchart, Chandan Mehta, Mohammed Rehman, Ariane Lewis, David Greer, Stephan A. Mayer, and Panayiotis N. Varelas
Expanding the clinical spectrum of the rare epilepsy syndrome of Benign Infantile Focal Epilepsy with Midline Spikes (BIMSE), Reema Butt, Jules Constantinou, and Muhammad S. Khan
Factors associated with outpatient follow-up in stroke clinic after discharge from a comprehensive stroke center, Reema Butt, Mohammed Ismail, Daniel J. Miller, Shaneela Malik, and Lonni Schultz
Double dorsiflexion sign (DDFS) and double finger tap sign (DFTS): More tricks in the neurologist's bag for assessing non-physiological weakness?, Reema Butt, Kavit Shah, Daniel Miller, and Lonni Schultz
Blood-based untargeted metabolomics in rrms revealed the testable therapeutic target, Mirela Cerghet, Laila M. Poisson, Hamid Suhail, Jaspreet Singh, Indrani Datta, A Mangalam, Stanton B. Elias, Ramandeep Rattan, and Shailendra Giri
Blood-based untargeted metabolomics in relapsing-remitting multiple sclerosis revealed testable therapeutic target, Shailendra Giri, Laila M. Poisson, Jaspreet Singh, Indrani Datta, Hamid Suhail, Ashutosh K. Mangalam, Mirela Cerghet, Stanton B. Elias, and Ramandeep Rattan
Early burst of glycolysis in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuro-inflammation, Shailendra Giri, Hamid Suhail, Jaspreet Singh, Ashok Kumar, and Ramandeep Rattan
Decreasing “door to admission” times for intravenous tPA treated patients: A single comprehensive stroke center experience, Tarun Girotra, Lee A. Raper, Lonni Schultz, Owais Alsrouji, Angelos Katramados, Lisa Cohen, Megan Brady, and Daniel J. Miller
Improving stroke care delivery for in-hospital stroke alerts by addition of overhead “code stroke” announcements: Single comprehensive stroke center's experience, Tarun Girotra, Lonni Schultz, Angelos Katramados, Megan Brady, Lisa Cohen, Lee A. Raper, and Daniel J. Miller
Health disparities in moyamoya, Khadija Irshad, Shaneela Malik, S Zahoor, and Lonni Schultz
Consent rate for organ donation after brain death: A single center's experience over 11.5 years, Mohammed Kananeh, Paul Brady, Lisa Louchart, Lonni R. Schultz, Chandan Mehta, Mohammed Rehman, Stephan A. Mayer, and Panayiotis N. Varelas
A widely accepted metric (telephone assessment of the modified Rankin scale score at 90 days) may not accurately reflect the real-life outcome of endovascular stroke treatment, Angelos Katramados, Panayiotis Mitsias, Hebah Hefzy, Shaneela Malik, Daniel J. Miller, Horia Marin, Maximillian K. Kole, Kyle Romanchuk, Konstantnos Marmagkiolis, Despina Tsitlakidou, Dawn Scozzarri, Lisa Cohen, Megan Brady, Panayiotis N. Varelas, and Stephan A. Mayer
