Gender and regional disparities in cardiomyopathy-related arrhythmias mortality: a 21-year analysis of CDC-WONDER (1999-2020)

Document Type

Conference Proceeding

Publication Date

11-5-2025

Publication Title

Eur Heart J

Keywords

adult, aged, cardiomyopathy, census tract, child, conference abstract, death toll, drug therapy, epidemiology, fatality, female, gender, heart arrhythmia, human, infant, major clinical study, male, middle aged, morbidity, mortality, mortality rate, sex difference, United States, very elderly

Abstract

Introduction: Cardiomyopathy-related arrhythmias contribute significantly to morbidity and mortality in the US, making them a serious public health concern. Disparities in death rates between genders and between areas continue to exist despite improvements in medical technology and care Purpose: The purpose of our study was to examine geographical and gender differences in the death rates of arrhythmias attributable to cardiomyopathy in the US from 1999 to 2020. The purpose of this study is to determine major mortality trends and annual percent changes (APCs) and to assess the differences in death rates between males and females as well as between census areas (Northeast, Midwest, South and West) Method: We analyzed mortality statistics from the CDC-WONDER database, focusing on deaths caused by arrhythmias related to cardiomyopathy from 1999 to 2020. Joinpoint regression analysis was applied to identify significant trends and annual percent changes (APCs) in mortality rates. The data was stratified by census regions (Northeast, Midwest, South, and West) and by gender (male and female). To assess disparities, we calculated crude rates, age-adjusted rates, and 95% confidence intervals (CIs).p<0.05 was considered to be significant Result: The findings indicated that the mortality rate due to arrhythmias associated with cardiomyopathy differed significantly between genders and geographical regions. For females, the mortality rate exhibited significant fluctuations over time, decreasing by 10.03% (APC: -10.03% [95% CI: -14.2, -5.6]) from 1999 to 2002, increasing by 5.71% (APC: 5.71% [95% CI: 1.2, 10.4]) between 2002 and 2005, declining again by 7.61% (APC: -7.61% [95% CI: -9.4, -5.7]) from 2005 to 2013, and remaining fairly stable before experiencing a slight uptick of 0.10% (APC: 0.10% [95% CI: -1.5, 1.7]) from 2013 to 2020. Meanwhile, between 1999 and 2016, the mortality rate for males fell by 5.50% (APC: -5.50% [95% CI: -6.4, -4.6]), but rose by 4.04% (APC: 4.04% [95% CI: 0.6, 7.6]) between 2016 and 2020. In terms of regional differences, the Northeast had the smallest population (989,744,746) and the fewest fatalities (7,945), whereas the South experienced the highest number of deaths (15,799) alongside the largest population (1,998,181,533). The age-adjusted mortality rate stood at 7.03 (95% CI: 6.88, 7.19) in the Northeast and 10.34 (95% CI: 10.16, 10.52) in the West. These findings highlight significant variations in death rates by region and gender throughout the study duration Conclusion: Over the 21-year span, significant variations in mortality rates from cardiomyopathy-related arrhythmias were observed based on region and gender. In contrast to males, female mortality rates showed more variation. The South and West exhibited higher mortality rates than the NE and Midwest. These findings highlight the urgent need for targeted treatments to address disparities in the mortality rates linked to arrhythmias caused by cardiomyopathy.

Volume

46

Find It @ Sladen

Share

COinS