BCL2-Rearrangment-Negative CD23+ Follicle Center Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Rare Case of Biclonal Composite Lymphoma

Authors

Hira Qadir, Henry Ford HealthFollow
Ejas Palathingal Bava, Henry Ford HealthFollow
Juan Gomez-Gelvez, Henry Ford HealthFollow
Wei Liu, Henry Ford HealthFollow
Kedar Inamdar, Henry Ford HealthFollow
Elizabeth Wey, Henry Ford HealthFollow
John Carey, jcarey1@hfhs.orgFollow
Yulei Shen, Henry Ford HealthFollow
Philip Kuriakose, Henry Ford HealthFollow
Sharmila Ghosh, Henry Ford HealthFollow

Recommended Citation

Qadir H, Palathingal Bava E, Gomez-Gelvez J, Liu W, Inamdar K, Wey E, Carey J, Shen Y, Kuriakose P, and Ghosh S. BCL2-Rearrangment-Negative CD23+ Follicle Center Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Rare Case of Biclonal Composite Lymphoma. Cureus 2025;17(7):e88727.

Document Type

Article

Publication Date

7-1-2025

Publication Title

Cureus

Abstract

Composite lymphomas are rare and diagnostically complex, comprising two or more distinct lymphoma subtypes within the same anatomical site and often requiring a comprehensive diagnostic approach. Due to their rarity and varied presentations, further research is needed to better understand their pathogenesis, clonal relationships, and optimal management strategies. This case report highlights an unusual presentation of composite lymphoma involving the coexistence of BCL2-R-negative, CD23-positive follicle center lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).

PubMed ID

40861583

Volume

17

Issue

7

First Page

88727

Last Page

88727