Association Of Dog Exposure and Early-Life IgE Production In The Microbes, Asthma, Allergy and Pets (MAAP) Birth Cohort
Recommended Citation
Elisa A, Chatfield A, Havstad S, Sitarik A, Kim H, Jones K, Wegienka G, Joseph C, Lukacs N, Johnson C, Ownby D, Lynch S, and Zoratti E. Association Of Dog Exposure and Early-Life IgE Production In The Microbes, Asthma, Allergy and Pets (MAAP) Birth Cohort. J Allergy Clin Immunol 2021; 147(2):AB162.
Document Type
Conference Proceeding
Publication Date
2-1-2021
Publication Title
J Allergy Clin Immunol
Abstract
Rationale: Early-life dog exposure has been associated with decreased IgE levels.
Methods: Pregnant women living with indoor dog(s) (n=81) and those with no pets (n=60) were recruited. Total IgE trajectories were constructed using serum samples collected at cord, 6 months and 18 months of age. Using mixed effects models, the trajectories were compared between infants from pet-free and dog-keeping households, and between dog-free, 1 dog only, and 2 or more dog households. Demographic variables were assessed as potential effect modifiers.
Results: Prenatal indoor dog exposure and the number of dogs was not associated with early life IgE (p=0.12 and 0.71, respectively). Infant sex was a significant modifier for both the binary dog and number of dogs outcomes (p=0.013 and p=0.024, respectively). For males, total IgE trajectory was 44.3% lower with prenatal indoor dog exposure (p=0.013), versus 39.3% higher for females (p=0.206). Compared to males without prenatal indoor dog exposure, total IgE trajectory was 34.7% lower when exposed to one dog (p=0.084), and 60.6% lower when exposed to 2 or more dogs (p=0.003). This effect was not observed in females (p=0.205).
Conclusions: Infant sex was a significant modifier in the relationship between prenatal dog exposure and early life IgE. Specifically, males with prenatal indoor dog exposure have lower early life total IgE trajectories than males without indoor pet exposure.
Volume
147
Issue
2
First Page
AB162