Hereditary Angioedema Severity and Poor Quality of Life Are Predictors on Occurrence of Sleep Disorders: The HAE SLEEP Study

Document Type

Conference Proceeding

Publication Date

2-1-2025

Publication Title

J Allergy Clin Immunol

Abstract

Rationale Understanding the relationship between HAE severity, quality of life (QoL), and the occurrence of various sleep disorders (SD) is critical for developing care strategies for HAE patients. This study aims to evaluate the impact of HAE severity and QoL, on the probability of developing different SD. Methods We conducted a logistic regression analysis using a sample of 139 individuals diagnosed with HAE. The primary predictor variables were the severity of HAE (severe vs. not severe) assessed by the HAE-AS, and QoL domains from the AE-QoL questionnaire. The outcomes were the presence of various sleep disorders. Odds ratios (OR) were calculated to determine the strength of associations, with statistical significance at p<0.05 level. Results The results indicated that severe HAE was strongly associated with Insomnia (OR = 2.620, p<0.01), OSA (OR = 2.400, p<0.05), RLS (OR = 5.854, p<0.01). Gender differences were notable in Insomnia, with males showing a lower probability compared to females (OR = 0.459, p<0.05). The AE-QoL domains significantly affected the odds of developing SD, Fatigue/Mood domain significantly increased the likelihood of Insomnia (OR = 1.087, p<0.01), Hypersomnolence (OR = 1.069, p<0.01), RLS (OR = 1.054, p<0.01), and OSA (OR = 1.040, p<0.01). Additionally, the Fears/Shame domain was a significant predictor for Insomnia (OR = 1.034, p<0.01), RLS (OR = 1.036, p<0.01), and OSA (OR = 1.014, p<0.1). Conclusions The severity of HAE and the level of impact on QoL, are significant predictors of multiple SD, indicating the necessity for targeted screening to improve the management of SD in this population.

Volume

155

Issue

2

First Page

1

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