Is it safe to administer neoadjuvant chemotherapy to patients undergoing hepatectomy for intrahepatic cholangiocarcinoma? ACS-NSQIP propensity-matched analysis
Recommended Citation
Choi WJ, Ivanics T, Claasen M, Gallinger S, Hansen B, and Sapisochin G. Is it safe to administer neoadjuvant chemotherapy to patients undergoing hepatectomy for intrahepatic cholangiocarcinoma? ACS-NSQIP propensity-matched analysis. HPB (Oxford) 2022; 24(9):1535-1542.
Document Type
Article
Publication Date
9-1-2022
Publication Title
HPB (Oxford)
Abstract
BACKGROUND: The use of neoadjuvant chemotherapy (NAC) in patients with intrahepatic cholangiocarcinoma (iCCA) is increasing. The objective of this study was to compare the 30-day post-operative complications and length-of-stay (LOS) between patients undergoing hepatectomy for iCCA with and without NAC.
METHODS: A retrospective study was conducted using the ACS-NSQIP database queried from 2014 to 2018. Patients with NAC receipt were propensity-score matched into 1:3 ratio with controls using the greedy-matching algorithm and a caliper of 0.2. Logistic and Poisson regression models were used to estimate the effect sizes.
RESULTS: A total of 1508 patients who underwent hepatectomy for iCCA were included. 706 patients remained after matching and balance were achieved. The NAC group had 110 (60.1%) complications vs. 289 (55.3%) complications in the non-NAC group (p = 0.29). NAC was not associated with worse 30-day postoperative complications [OR 1.24, 95% CI: 0.87-1.76; p = 0.24]. Post-operative LOS in the NAC group was 8.56 days (mean, SD 7.4) vs. non-NAC group 9.27 days (mean, SD 8.41, p = 0.32). NAC was not associated with longer post-operative LOS [RR 0.93, 95% CI:0.80, 1.08; p = 0.32].
CONCLUSION: NAC may be safely administered without increasing the risk of 30-day complications or post-operative hospital LOS.
Medical Subject Headings
Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Hepatectomy; Humans; Neoadjuvant Therapy; Postoperative Complications; Propensity Score; Retrospective Studies
PubMed ID
35474005
Volume
24
Issue
9
First Page
1535
Last Page
1542
