Independent predictors and timing of portomesenteric vein thrombosis after bariatric surgery

Document Type

Article

Publication Date

12-1-2022

Publication Title

Surg Obes Relat Dis

Abstract

BACKGROUND: Portomesenteric vein thrombosis (PVT) is a rare complication following bariatric surgery but can result in severe morbidity as well as death.

OBJECTIVE: Identification of risk factors for PVT to facilitate targeted management strategies to reduce incidence.

SETTING: Prospective, statewide bariatric-specific clinical registry.

METHODS: We identified all patients who underwent primary bariatric surgery between June 2006 and November 2021 (n = 102,869). Patient characteristics, procedure type, operative details, and 30-day postoperative complications were analyzed with multivariable logistic regression to evaluate for independent predictors of PVT.

RESULTS: A total of 117 patients (.11%) developed a postoperative PVT, with 6 (5.1%) associated deaths. The majority of PVTs occurred in patients who underwent sleeve gastrectomy (109 patients; 93.2%), and the PVT occurred most commonly during the second (37%), third (31%), and fourth weeks (23%) after surgery. Independent risk factors for PVT included a prior history of venous thromboembolism (odds ratio [OR] = 3.1; 95% confidence interval [CI]: 1.64-5.98; P = .0005), liver disorder (OR = 2.3; 95% CI: 1.36-4.00; P = .0021), undergoing sleeve gastrectomy (OR = 12.4; 95% CI: 4.98-30.69; P < .0001), and postoperative complications including obstruction (OR = 12.5; 95% CI: 4.65-33.77; P < .0001), leak (OR = 7.9; 95% CI: 2.76-22.64; P = .0001), and hemorrhage (OR = 7.6; 95% CI: 3.57-16.06; P < .0001).

CONCLUSIONS: Independent predictors of PVT include a prior history of venous thromboembolism, liver disease, undergoing sleeve gastrectomy, and experiencing a serious postoperative complication. Given that the incidence of PVT is most common within the first month after surgery, extending postdischarge chemoprophylaxis during this time frame is advised for patients with increased risk.

Medical Subject Headings

Humans; Obesity, Morbid; Mesenteric Veins; Venous Thromboembolism; Prospective Studies; Portal Vein; Aftercare; Laparoscopy; Patient Discharge; Bariatric Surgery; Venous Thrombosis; Gastrectomy; Postoperative Complications

PubMed ID

36198496

Volume

18

Issue

12

First Page

1385

Last Page

1391

Find It @ Sladen

Share

COinS