Poor Glycemic Control Is a Risk Factor for Triple- Negative Breast Cancer in Patients With Type 2 Diabetes

Document Type

Conference Proceeding

Publication Date

5-1-2022

Publication Title

Obstet Gynecol

Abstract

INTRODUCTION: We sought to investigate the relationship between glycemic control, race, and the incidence of triple-negative breast cancer (TNBC) among patients with type 2 diabetes (T2D). METHODS: A retrospective cohort study evaluating 1,416 patients with T2D diagnosed with breast cancer between 2015 and 2020 was conducted. Tumor subtype was categorized as either hormone receptor-positive (ER+, PR+, or both) or triple-negative (ER/PRand HER2/neu-). Based on Hgb A1c measured within 3 months of cancer diagnosis, patients were assigned to one of three categories: well-controlled (Hgb A1c less than 7.0), moderately controlled (Hgb A1c 7.0-9.4), or poorly controlled (Hgb A1c greater than or equal to 9.5) T2D. RESULTS: A significant increase in the percentage of non-Hispanic White patients with TNBC across the three levels of glycemic control was observed (P=.037). When racial comparisons of cancer subtype within categories of glycemic control were performed, a significant (P=.001) increase in the percentage of Black patients with TNBC compared with non-Hispanic White patients was only observed among those with well-controlled T2D. CONCLUSION: Although previous studies have shown that Black patients are 2 to 3 times more likely to develop TNBC than their non- Hispanic White counterparts, a statistically significant racial difference was only noted among our patients with well-controlled T2D. Thus, our data not only suggest that T2D may serve as a modifiable risk factor for the development of TNBC but also that the risk conferred by poor glycemic control may bear more significance for non-Hispanic White patients than Black patients.

Volume

139

Issue

SUPPL 1

First Page

93S

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