Scholarly journal articles authored by members of the Division of Cardiology/Cardiovascular Research at Henry Ford Health.

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Submissions from 2018

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The Role of Mechanical Circulatory Support During Percutaneous Coronary Intervention in Patients Without Severely Depressed Left Ventricular Function, Khaldoon Alaswad, Mir B. Basir, Akshay Khandelwal, Theodore Schreiber, William Lombardi, and William O'Neill

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Mechanical Circulatory Support in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Multicenter US Registry, Barbara A. Danek, Mir B. Basir, William O'Neill, Mohammad Alqarqaz, Aris Karatasakis, Dimitri Karmpaliotis, Farouc A. Jaffer, Robert W. Yeh, Michael Wyman, William L. Lombardi, David Kandzari, Nicholas Lembo, Anthony Doing, Mitul Patel, Ehtisham Mahmud, James W. Choi, Catalin Toma, Jeffrey W. Moses, Ajay Kirtane, Manish Parikh, Ziad A. Ali, Santiago Garcia, Judit Karacsonyi, Bavana V. Rangan, Craig A. Thompson, Subhash Banerjee, Emmanouil S. Brilakis, and Khaldoon Alaswad

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Contrast-Induced Nephropathy in STEMI Patients With and Without Chronic Kidney Disease, Tarun Jain, Sunay Shah, Jainil Shah, Gordon Jacobsen, and Akshay Khandelwal

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Coronary artery disease reporting and data system (CAD-RADS, Christopher D. Maroules, Christian Hamilton-Craig, Kelley Branch, James Lee, Roberto C. Cury, Pál Maurovich-Horvat, Ronen Rubinshtein, Dustin Thomas, Michelle Williams, Yanshu Guo, and Ricardo C. Cury

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Prevalence, Presentation and Treatment of 'Balloon Undilatable' Chronic Total Occlusions: Insights from a Multicenter US Registry, Peter Tajti, Dimitri Karmpaliotis, Khaldoon Alaswad, Catalin Toma, James W. Choi, Farouc A. Jaffer, Anthony H. Doing, Mitul Patel, Ehtisham Mahmud, Barry Uretsky, Aris Karatasakis, Judit Karacsonyi, Barbara A. Danek, Bavana V. Rangan, Subhash Banerjee, Imre Ungi, and Emmanouil S. Brilakis

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Feasibility of early mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock: The Detroit cardiogenic shock initiative, Mir B. Basir, Theodore Schreiber, Simon Dixon, Khaldoon Alaswad, Kirit Patel, Steven Almany, Akshay Khandelwal, Ivan Hanson, Augustine George, Michael Ashbrook, Nimrod Blank, Murad Abdelsalam, Nishtha Sareen, Steven BH Timmis, and William O'Neill

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Randomized Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusions: The CrossBoss First Trial, Judit Karacsonyi, Peter Tajti, Bavana V. Rangan, Sean C. Halligan, Raymond H. Allen, William J. Nicholson, James E. Harvey, Anthony J. Spaedy, Farouc A. Jaffer, J A. Grantham, Adam Salisbury, Anthony J. Hart, David M. Safley, William L. Lombardi, Ravi Hira, Creighton Don, James M. McCabe, M N. Burke, Khaldoon Alaswad, Gerald C. Koenig, Kintur A. Sanghvi, Daniel Ice, Richard C. Kovach, Vincent Varghese, Bilal Murad, Kenneth W. Baran, Erica Resendes, Jose R. Martinez-Parachini, Aris Karatasakis, Barbara A. Danek, Rahel Iwnetu, Michele Roesle, Houman Khalili, Subhash Banerjee, and Emmanouil S Brilakis

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Association of Cardiac Rehabilitation With Decreased Hospitalizations and Mortality After Ventricular Assist Device Implantation, Justin M. Bachmann, Meredith S. Duncan, Ashish S. Shah, Robert A. Greevy, JoAnn Lindenfeld, Steven J. Keteyian, Randal J. Thomas, Mary A. Whooley, Thomas J. Wang, and Matthew S. Freiberg

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Exercise Oscillatory Ventilation: Interreviewer Agreement and a Novel Determination, Clinton Brawner, Jonathan K. Ehrman, Jonathan Myers, Paul Chase, Baruch Vainshelboim, Shadi Farha, Matthew A. Saval, Rita McGuire, Bunny Pozehl, and Steven J. Keteyian

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Challenges with Percent Predicted Maximal V˙O2 in Patients with Heart Failure, Clinton Brawner, Jonathan K. Ehrman, Ali Shafiq, Matthew A. Saval, Stuart D. Russell, David Lanfear, and Steven J. Keteyian

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Determinants of Variation in Pneumonia Rates After Coronary Artery Bypass Grafting, Alexander A. Brescia, J S. Rankin, Derek D. Cyr, Jeffrey P. Jacobs, Richard L. Prager, Min Zhang, Roland A. Matsouaka, Steven D. Harrington, Rachel S. Dokholyan, Steven F. Bolling, Astrid Fishstrom, Sara K. Pasquali, David M. Shahian, and Donald S. Likosky

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Reduced Myocardial Flow Reserve Is Associated With Diastolic Dysfunction and Decreased Left Atrial Strain in Patients With Normal Ejection Fraction and Epicardial Perfusion, Matthew C. Konerman, Joshua C. Greenberg, Theodore J. Kolias, James R. Corbett, Ravi V. Shah, Venkatesh L. Murthy, and Scott L. Hummel

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Reliability of the 123I-mIBG heart/mediastinum ratio: Results of a multicenter test-retest reproducibility study, Timothy M. Bateman, Karthikeyan Ananthasubramaniam, Daniel S. Berman, Myron Gerson, Robert Gropler, Milena Henzlova, Fernando Mendoza, Michael Miyamoto, Mahesh Shah, and Frederick Weiland

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Primary percutaneous coronary intervention at centers with and without on-site surgical support: Insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2), Majed Afana, Hitinder S. Gurm, Milan Seth, Kathleen M. Frazier, Sheryl Fielding, and Gerald C. Koenig

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Prognostic value of circulating microRNAs on heart failure-related morbidity and mortality in two large diverse cohorts of general heart failure patients, Antoni Bayés-Genis, David Lanfear, Maurice WJ de Ronde, Josep Lupón, Joost J. Leenders, Zhen Liu, Nicolaas PA Zuithoff, Marinus JC Eijkemans, Elisabet Zamora, Marta De Antonio, Aeilko H. Zwinderman, Sara-Joan Pinto-Sietsma, and Yigal M. Pinto

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What's Next for Acute Heart Failure Research?, Sean P. Collins, Phillip D. Levy, Gregory J. Fermann, Michael M. Givertz, Jennifer M. Martindale, Peter S. Pang, Alan B. Storrow, Deborah D. Diercks, G Michael Felker, Gregg C. Fonarow, David Lanfear, Daniel J. Lenihan, JoAnn M. Lindenfeld, W F. Peacock, Douglas M. Sawyer, John R. Teerlink, and Javed Butler

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Quality of life and functional capacity outcomes in the MOMENTUM 3 trial at 6 months: A call for new metrics for left ventricular assist device patients, Jennifer A. Cowger, Yoshifumi Naka, Keith D. Aaronson, Douglas Horstmanshof, Sanjeev Gulati, Debbie Rinde-Hoffman, Sean Pinney, Sirtaz Adatya, David J. Farrar, and Ulrich P. Jorde

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Transseptal transcatheter mitral valve replacement for post-surgical mitral failures, Marvin H. Eng and Dee Dee Wang

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Chronic intestinal pseudo-obstruction due to, Jenna Greenberg, Joshua C. Greenberg, and Nicholas Helmstetter

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An unusual ECG deflection: Fact or artifact?, Daniel F. Kupsky, Marc K. Lahiri, and Claudio Schuger

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Using machine learning on cardiorespiratory fitness data for predicting hypertension: The Henry Ford ExercIse Testing (FIT) Project, Sherif Sakr, Radwa Elshawi, Amjad Ahmed, Waqas T. Qureshi, Clinton Brawner, Steven J. Keteyian, Michael J. Blaha, and Mouaz H. Al-Mallah

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The Coronary Artery Disease-Reporting and Data System (CAD-RADS): Prognostic and Clinical Implications Associated With Standardized Coronary Computed Tomography Angiography Reporting, Joe X. Xie, Ricardo C. Cury, Jonathon Leipsic, Matthew T. Crim, Daniel S. Berman, Heidi Gransar, Matthew J. Budoff, Stephan Achenbach, Bríain Ó Hartaigh, Tracy Q. Callister, Hugo Marques, Ronen Rubinshtein, Mouaz H. Al-Mallah, Daniele Andreini, Gianluca Pontone, Filippo Cademartiri, Erica Maffei, Kavitha Chinnaiyan, Gilbert Raff, Martin Hadamitzky, Joerg Hausleiter, Gudrun Feuchtner, Allison Dunning, Augustin DeLago, Yong-Jin Kim, Philipp A. Kaufmann, Todd C. Villines, Benjamin JW Chow, Niree Hindoyan, Millie Gomez, Fay Y. Lin, Erica Jones, James K Min, and Leslee J Shaw

Submissions from 2017

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Comparison of machine learning techniques to predict all-cause mortality using fitness data: the Henry ford exercIse testing (FIT) project, Sherif Sakr, Radwa Elshawi, Amjad M. Ahmed, Waqas T. Qureshi, Clinton Brawner, Steven J. Keteyian, Michael J. Blaha, and Mouaz H. Al-Mallah

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Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA), Stephen T. Broughton, Wesley T. O'Neal, Mouaz H. Al-Mallah, David A. Bluemke, Susan R. Heckbert, Joao AC Lima, and Elsayed Z. Soliman

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Pharmacogenomics of the Natriuretic Peptide System in Heart Failure, Ahmed Abuzaanona and David Lanfear

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Using Machine Learning to Define the Association between Cardiorespiratory Fitness and All-Cause Mortality (from the Henry Ford Exercise Testing Project), Mouaz H. Al-Mallah, Radwa Elshawi, Amjad M. Ahmed, Waqas T. Qureshi, Clinton Brawner, Michael J. Blaha, Haitham M. Ahmed, Jonathan K. Ehrman, Steven J. Keteyian, and Sherif Sakr

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Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a MADIT-RIT substudy, Usama A. Daimee, Katherine Vermilye, Spencer Rosero, Claudio Schuger, James P. Daubert, Wojciech Zareba, Scott McNitt, Bronislava Polonsky, Arthur J. Moss, and Valentina Kutyifa

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Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide, Melissa A. Daubert, Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S. Douglas, Christopher O'Connor, Sidney Goldstein, James E. Udelson, and Hani N. Sabbah

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Short-term results of alcohol septal ablation as a bail-out strategy to treat severe left ventricular outflow tract obstruction after transcatheter mitral valve replacement in patients with severe mitral annular calcification, Mayra Guerrero, Dee Dee Wang, Dominique Himbert, Marina Urena, Amit Pursnani, Georges Kaddissi, Vijay Iyer, Michael Salinger, Tarun Chakravarty, Adam Greenbaum, Raj Makkar, Alec Vahanian, Ted Feldman, and William O'Neill

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Thoracic extra-coronary calcification for the prediction of stroke: The Multi-Ethnic Study of Atherosclerosis, Sina Kianoush, Mahmoud Al Rifai, Miguel Cainzos-Achirica, Mouaz H. Al-Mallah, Geoffrey H. Tison, Joseph Yeboah, Michael D. Miedema, Matthew A. Allison, Nathan D. Wong, Andrew P. DeFilippis, William Longstreth, Khurram Nasir, Matthew J. Budoff, Kunihiro Matsushita, and Michael J. Blaha

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High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study, Richard M. Nowak, Christian Mueller, Evangelos Giannitsis, Michael Christ, Jordi Ordonez-Llanos, Christopher DeFilippi, James McCord, Richard Body, Mauro Panteghini, Tomas Jernberg, Mario Plebani, Franck Verschuren, John K. French, Robert Christenson, Gordon Jacobsen, Carina Dinkel, and Bertil Lindahl

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Socioeconomic and Racial Disparities: a Case-Control Study of Patients Receiving Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis, Anna Sleder, Shiloh Tackett, Matthew Cerasale, Chetan Mittal, Iyad Isseh, Ryhm Radjef, Andrew Taylor, Rashad Farha, Oleksandra Lupak, Dana Larkin, Lois Lamerato, George Divine, Kimberlydawn Wisdom, Kimberly Baker-Genaw, and William O'Neill

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Ninety-Day Readmission and Long-Term Mortality in Medicare Patients (≥65 Years) Treated With Ticagrelor Versus Prasugrel After Percutaneous Coronary Intervention (from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium), Chris Song, Devraj Sukul, Milan Seth, James M. Dupree, Akshay Khandelwal, Simon R. Dixon, David Wohns, Thomas LaLonde, and Hitinder S. Gurm

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Power of gradients, Pradeep Yadav and Marvin H. Eng

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Targeted Metabolomic Profiling of Plasma and Survival in Heart Failure Patients, David Lanfear, Joseph J. Gibbs, Jia Li, Ruicong She, Christopher Petucci, Jeffrey A. Culver, W HW Tang, Yigal M. Pinto, Keoki L. Williams, Hani N. Sabbah, and Stephen J. Gardell

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Pathophysiology of acute heart failure syndrome: a knowledge gap, Hani N. Sabbah

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The comparative safety and effectiveness of bivalirudin versus heparin monotherapy in patients on dialysis undergoing percutaneous coronary intervention: Insights from the Blue Cross Blue Shield of Michigan cardiovascular consortium, Devraj Sukul, Milan Seth, Theodore Schreiber, Akshay Khandelwal, Louis A. Cannon, Thomas A. LaLonde, and Hitinder S. Gurm

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The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology, Marc van Bilsen, Hitesh C. Patel, Johann Bauersachs, Michael Böhm, Martin Borggrefe, Dirk Brutsaert, Andrew JS Coats, Rudolf A. de Boer, Gilles W. de Keulenaer, Gerasimos S. Filippatos, John Floras, Guido Grassi, Ewa A. Jankowska, Lilian Kornet, Ida G. Lunde, Christoph Maack, Felix Mahfoud, Piero Pollesello, Piotr Ponikowski, Frank Ruschitzka, Hani N. Sabbah, Harold D. Schultz, Petar Seferovic, Riemer HJA Slart, Peter Taggart, Carlo G. Tocchetti, Linda W. Van Laake, Faiez Zannad, Stephane Heymans, and Alexander R Lyon

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Inflammatory Biomarkers Interleukin-6 and C-Reactive Protein and Outcomes in Stable Coronary Heart Disease: Experiences From the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial, Claes Held, Harvey D. White, Ralph AH Stewart, Andrzej Budaj, Christopher P. Cannon, Judith S. Hochman, Wolfgang Koenig, Agneta Siegbahn, Philippe G. Steg, Joseph Soffer, W D. Weaver, Ollie Östlund, and Lars Wallentin

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Death and Dialysis After Transcatheter Aortic Valve Replacement: An Analysis of the STS/ACC TVT Registry, James WJ Hansen, Andrew Foy, Pradeep Yadav, Ian C. Gilchrist, Mark Kozak, Amanda Stebbins, Roland Matsouaka, Sreekanth Vemulapalli, Alice Wang, Dee Dee Wang, Marvin H. Eng, Adam B. Greenbaum, and William O'Neill

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Incidence, Treatment, and Outcomes of Coronary Perforation During Chronic Total Occlusion Percutaneous Coronary Intervention, Barbara A. Danek, Aris Karatasakis, Peter Tajti, Yader Sandoval, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert W. Yeh, David E. Kandzari, Nicholas J. Lembo, Mitul P. Patel, Ehtisham Mahmud, James W. Choi, Anthony H. Doing, William L. Lombardi, R M. Wyman, Catalin Toma, Santiago Garcia, Jeffrey W. Moses, Ajay J. Kirtane, Raja Hatem, Ziad A. Ali, Manish Parikh, Judit Karacsonyi, Bavana V. Rangan, Houman Khalili, M N. Burke, Subhash Banerjee, and Emmanouil S. Brilakis

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Mitral Annuloplasty Ring Fracture and Annular Injury During Transcatheter Mitral Valve-in-Ring Intervention, Tiberio M. Frisoli, Dee Dee Wang, Marvin H. Eng, William O'Neill, Gaetano Paone, and Adam B. Greenbaum

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Protein turnover in the failing heart: an ever-changing landscape, Baljash S. Cheema, Hani N. Sabbah, Stephen J. Greene, and Mihai Gheorghiade

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Impact of Center Left Ventricular Assist Device Volume on Outcomes After Implantation: An INTERMACS Analysis, Jennifer A. Cowger, John M. Stulak, Palak Shah, Todd F. Dardas, Francis D. Pagani, Shannon M. Dunlay, Simon Maltais, Keith D. Aaronson, Ramesh Singh, Nahush A. Mokadam, James K. Kirklin, and Christopher T. Salerno

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Cardiorespiratory Fitness Change and Mortality Risk Among Black and White Patients: Henry Ford Exercise Testing (FIT) Project, Jonathan K. Ehrman, Clinton Brawner, Mouaz H. Al-Mallah, Waqas T. Qureshi, Michael J. Blaha, and Steven J. Keteyian

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Henry Ford HEART Score Randomized Trial: Rapid Discharge of Patients Evaluated for Possible Myocardial Infarction, Tiberio M. Frisoli, Richard M. Nowak, Kaleigh L. Evans, Michael F. Harrison, Maath Alani, Saira Varghese, Mehnaz Rahman, Samantha Noll, Katherine R. Flannery, Alexander T. Michaels, Mishel Tabaku, Gordon Jacobsen, and James McCord

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An ISHLT consensus document for prevention and management strategies for mechanical circulatory support infection, Shimon Kusne, Martha Mooney, Lara Danziger-Isakov, Annemarie Kaan, Lars H. Lund, Haifa Lyster, Georg Wieselthaler, Saima Aslam, Barbara Cagliostro, Jonathan Chen, Pamela Combs, Adam Cochrane, Jennifer Conway, Jennifer A. Cowger, Maria Frigerio, Rochelle Gellatly, Paolo Grossi, Finn Gustafsson, Margaret Hannan, Angela Lorts, Stanley Martin, Sean Pinney, Fernanda P. Silveira, Stephan Schubert, Stephan Schueler, Martin Strueber, Nir Uriel, Neil Wrightson, Rachel Zabner, and Shirish Huprikar

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Contemporary Trends and Outcomes Associated With the Preprocedural Use of Oral P2Y12 Inhibitors in Patients Undergoing Percutaneous Coronary Intervention: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2), Devraj Sukul, Milan Seth, Simon R. Dixon, Akshay Khandelwal, Thomas A. LaLonde, and Hitinder S. Gurm

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A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction, Cristina Tita, Edward M. Gilbert, Adrian B. Van Bakel, Jacek Grzybowski, Garrie J. Haas, Mohammad Jarrah, Stephanie H. Dunlap, Stephen S. Gottlieb, Marc Klapholz, Parag C. Patel, Roman Pfister, Tim Seidler, Keyur B. Shah, Tomasz Zieliński, Robert P. Venuti, Douglas Cowart, Shi Yin Foo, Alexander Vishnevsky, and Veselin Mitrovic

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Trends in Use of Biomarker Protocols for the Evaluation of Possible Myocardial Infarction, Brian J. Hachey, Michael C. Kontos, L K. Newby, Robert H. Christenson, W F. Peacock, Katherine C. Brewer, and James McCord

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Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study, Catherine Gebhard, Ronny R. Buechel, Barbara E. Stähli, Heidi Gransar, Stephan Achenbach, Daniel S. Berman, Matthew J. Budoff, Tracy Q. Callister, Benjamin Chow, Allison Dunning, Mouaz H. Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Ronen Rubinshtein, Hugo Marques, Augustin DeLago, Todd C. Villines, Martin Hadamitzky, Joerg Hausleiter, Leslee J. Shaw, Ricardo C. Cury, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk-Jae Chang, Jonathon Leipsic, James K. Min, and Philipp A. Kaufmann

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The (Dis) Utility of a Change in Troponin I for Diagnosis of Non-ST-Segment Elevation Myocardial Infarction in an Observation Unit, Iani Patsias, Benjamin Swanson, Michael Hudson, Sachin Parikh, Khaled Abdul-Nour, Gordon Jacobsen, and James McCord

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Relation of Exercise Capacity to Risk of Development of Diabetes in Patients on Statin Therapy (the Henry Ford Exercise Testing Project), Gabriel E. Shaya, Stephen P. Juraschek, David I. Feldman, Clinton Brawner, Jonathan K. Ehrman, Steven J. Keteyian, Mouaz H. Al-Mallah, and Michael J. Blaha

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Transcatheter Mitral Valve Repair With MitraClip for Symptomatic Functional Mitral Valve Regurgitation, Rodrigo Mendirichaga, Vikas Singh, Vanessa Blumer, Manuel Rivera, Alex P. Rodriguez, Mauricio G. Cohen, William O'Neill, and Sammy Elmariah

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Sex-Specific Maximum Predicted Heart Rate and Its Prognosis for Mortality and Myocardial Infarction, Haitham M. Ahmed, Mouaz H. Al-Mallah, Steven J. Keteyian, Clinton Brawner, Jonathan K. Ehrman, D I. Zhao, Eliseo Guallar, Michael J. Blaha, and Erin D. Michos

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Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures, Marvin H. Eng, Adam Greenbaum, Dee Dee Wang, Janet Wyman, Heider Arjomand, Pradeep Yadav, Hassan Nemeh, Gaetano Paone, Mayra Guerrero, and William O'Neill

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The Impact of Proximal Vessel Tortuosity on the Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Contemporary Multicenter Registry, Judit Karacsonyi, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A. Jaffer, Robert W. Yeh, Mitul Patel, Ehtisham Mahmud, Anthony Doing, Catalin Toma, Barry Uretsky, James Choi, Jeffrey W. Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, William L. Lombardi, David E. Kandzari, Nicholas Lembo, Santiago Garcia, Michael R. Wyman, Jose R. Martinez-Parachini, Aris Karatasakis, Barbara A. Danek, Aya J. Alame, Erica Resendes, BavanA V. Rangan, Imre Ungi, Craig A. Thompson, Subhash Banerjee, and Emmanouil S. Brilakis

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Outcomes of hemodynamic support with Impella in very high-risk patients undergoing balloon aortic valvuloplasty: Results from the Global cVAD Registry, Vikas Singh, Pradeep K. Yadav, Marvin H. Eng, Francisco Y. Macedo, Guilherme V. Silva, Rodrigo Mendirichaga, Amit P. Badiye, Rahul Sakhuja, Sammy Elmariah, Ignacio Inglessis, Carlos E. Alfonso, Theodore L. Schreiber, Mauricio Cohen, Igor Palacios, and William O'Neill

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The comparative safety of abciximab versus eptifibatide in patients on dialysis undergoing percutaneous coronary intervention: Insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2), Devraj Sukul, Milan Seth, Theodore Schreiber, George Hanzel, Akshay Khandelwal, Louis A. Cannon, Thomas A. Lalonde, and Hitinder S. Gurm

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Prognostic Significance of Nonobstructive Left Main Coronary Artery Disease in Women Versus Men: Long-Term Outcomes From the CONFIRM (Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter) Registry, Joe X. Xie, Parham Eshtehardi, Tina Varghese, Abhinav Goyal, Puja K. Mehta, William Kang, Jonathon Leipsic, Bríain Ó Hartaigh, C N. Bairey Merz, Daniel S. Berman, Heidi Gransar, Matthew J. Budoff, Stephan Achenbach, Tracy Q. Callister, Hugo Marques, Ronen Rubinshtein, Mouaz H. Al-Mallah, Daniele Andreini, Gianluca Pontone, Filippo Cademartiri, Erica Maffei, Kavitha Chinnaiyan, Gilbert Raff, Martin Hadamitzky, Joerg Hausleiter, Gudrun Feuchtner, Philipp A. Kaufmann, Todd C. Villines, Benjamin J W Chow, James K Min, and Leslee J. Shaw

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Prognostic Value of Serial N-Terminal Pro-Brain Natriuretic Peptide Testing in Patients With Acute Myocardial Infarction, Michael C. Kontos, David Lanfear, Kensey Gosch, Stacie L. Daugherty, Paul Heidenriech, and John A. Spertus

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Introduction to the Special Issue: Myocardial Imaging in Heart Failure, Mouaz H. Al-Mallah

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Further validation of the hybrid algorithm for CTO PCI; difficult lesions, same success, Mir B. Basir, Aris Karatasakis, Mohammad Alqarqaz, Barbara Danek, Bavana V. Rangan, Emmanouil S. Brilakis, Haejin Kim, William O'Neill, and Khaldoon Alaswad

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Prognostic implications of coronary artery calcium in the absence of coronary artery luminal narrowing, Iksung Cho, Bríain Ó Hartaigh, Heidi Gransar, Valentina Valenti, Fay Y. Lin, Stephan Achenbach, Daniel S. Berman, Matthew J. Budoff, Tracy Q. Callister, Mouaz H. Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin JW Chow, Allison M. Dunning, Augustin DeLago, Todd C. Villines, Martin Hadamitzky, Joerg Hausleiter, Jonathon Leipsic, Leslee J. Shaw, Philippe A. Kaufmann, Ricardo C. Cury, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk-Jae Chang, and James K. Min

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Coronary artery spatial distribution of chronic total occlusions: Insights from a large US registry, Santiago Garcia, M Alraies, Aris Karatasakis, Demetris Yannopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A. Jaffer, Robert W. Yeh, Mitul P. Patel, John Bahadorani, Judit Karacsonyi, Pratik Kalsaria, Barbara Danek, Subhash Banerjee, and Emmanouil S. Brilakis

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Prevalence, indications and management of balloon uncrossable chronic total occlusions: Insights from a contemporary multicenter US registry, Judit Karacsonyi, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A. Jaffer, Robert W. Yeh, Mitul Patel, John Bahadorani, Anthony Doing, Ziad A. Ali, Aris Karatasakis, Barbara A. Danek, Bavana V. Rangan, Aya J. Alame, Subhash Banerjee, and Emmanouil S. Brilakis

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Impact of Calcium on Chronic Total Occlusion Percutaneous Coronary Interventions, Judit Karacsonyi, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A. Jaffer, Robert W. Yeh, Mitul Patel, Ehtisham Mahmud, William Lombardi, Michael R. Wyman, Anthony Doing, Jeffrey W. Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, David Kandzari, Nicholas Lembo, Santiago Garcia, Barbara A. Danek, Aris Karatasakis, Erica Resendes, Pratik Kalsaria, Bavana V. Rangan, Imre Ungi, Craig A. Thompson, Subhash Banerjee, and Emmanouil S. Brilakis

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Exercise Training Workloads Upon Exit From Cardiac Rehabilitation in Men and Women: THE HENRY FORD HOSPITAL EXPERIENCE, Steven J. Keteyian, Dennia Kerrigan, Jonathan K. Ehrman, and Clinton Brawner

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Multicenter Automatic Defibrillator Implantation Trial-Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol, Valentina Kutyifa, Christopher Beck, Mary W. Brown, David Cannom, James Daubert, Mark Estes, Henry Greenberg, Ilan Goldenberg, Stephen Hammes, David Huang, Helmut Klein, Reinoud Knops, Mikhail Kosiborod, Jeanne Poole, Claudio Schuger, Jagmeet P. Singh, Scott Solomon, David Wilber, Wojciech Zareba, and Arthur J. Moss

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Effects of implantable cardioverter/defibrillator shock and antitachycardia pacing on anxiety and quality of life: A MADIT-RIT substudy, Alessandro P. Perini, Valentina Kutyifa, Peter Veazie, James P. Daubert, Claudio Schuger, Wojciech Zareba, Scott McNitt, Spencer Rosero, Christine Tompkins, Luigi Padeletti, and Arthur J. Moss

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Ventricular Septal Defect Complicating ST-Elevation Myocardial Infarctions: A Call for Action, Vikas Singh, Alex P. Rodriguez, Parth Bhatt, Carlos E. Alfonso, Rahul Sakhuja, Igor F. Palacios, Ignacio Inglessis-Azuaje, Mauricio G. Cohen, Sammy Elmariah, and William O'Neill

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Do We Need Another Walking Test?, Clinton Brawner and Steven J. Keteyian

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Impella 25 initiated prior to unprotected left main PCI in acute myocardial infarction complicated by cardiogenic shock improves early survival, Perwaiz M. Meraj, Rajkumar Doshi, Theodore Schreiber, Brijeshwar Maini, and William O'Neill

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Employing Extracellular Volume Cardiovascular Magnetic Resonance Measures of Myocardial Fibrosis to Foster Novel Therapeutics, Erik B. Schelbert, Hani N. Sabbah, Javed Butler, and Mihai Gheorghiade

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Guiding coronary revascularization using PET stress myocardial perfusion imaging: The proof is in the pudding, Ajay V. Srivastava and Karthikeyan Ananthasubramaniam

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The EXERRT trial: "EXErcise to Regadenoson in Recovery Trial": A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol, Gregory S. Thomas, S J. Cullom, Therese M. Kitt, Kathleen M. Feaheny, Karthikeyan Ananthasubramaniam, Robert J. Gropler, Diwakar Jain, and Randall C. Thompson

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Electrocardiographic Predictors of Heart Failure With Reduced Versus Preserved Ejection Fraction: The Multi-Ethnic Study of Atherosclerosis, Wesley T. O'Neal, Matylda Mazur, Alain G. Bertoni, David A. Bluemke, Mouaz H. Al-Mallah, Joao AC Lima, Dalane Kitzman, and Elsayed Z. Soliman

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Respect the Septal Perforator: Septal Artery Perforation During CTO PCI Resulting in Massive Interventricular Septal Hematoma and Biventricular Cardiac Obstructive Shock, Tiberio M. Frisoli, Majed Afana, Sagger Mawri, Mazen Hadid, Luay Sayed, William O'Neill, Dee Dee Wang, Sachin Parikh, Akshay Khandelwal, and Khaldoon Alaswad

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Practical data handling pipeline improves performance of qPCR-based circulating miRNA measurements, Maurice WJ de Ronde, Jan M. Ruijter, David Lanfear, Antoni Bayes-Genis, Maayke GM Kok, Esther E. Creemers, Yigal M. Pinto, and Sara-Joan Pinto-Sietsma

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Cardiac tamponade due to pyopneumopericardium from malignant bronchopericardial fistula, Tiberio M. Frisoli, Tarun Jain, T Swadia, X Hong, and M Guerrero

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Redefining the role of biomarkers in heart failure trials: expert consensus document, Frank Kramer, Hani N. Sabbah, James J. Januzzi, Faiez Zannad, J Peter van Tintelen, Erik B. Schelbert, Raymond J. Kim, Hendrik Milting, Richardus Vonk, Brien Neudeck, Richard Clark, Klaus Witte, Wilfried Dinh, Burkert Pieske, Javed Butler, and Mihai Gheorghiade

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Accuracy of Seattle Heart Failure Model and HeartMate II Risk Score in Non-Inotrope-Dependent Advanced Heart Failure Patients: Insights From the ROADMAP Study (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients), David Lanfear, Wayne C. Levy, Josef Stehlik, Jerry D. Estep, Joseph G. Rogers, Keyur B. Shah, Andrew J. Boyle, Joyce Chuang, David J. Farrar, and Randall C. Starling

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Therapeutic Cardiorespiratory Fitness to Prevent and Treat Heart Failure, Carl J. Lavie, Steven J. Keteyian, and Hector O. Ventura

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Coronary artery perforations after contemporary percutaneous coronary interventions: Evaluation of incidence, risk factors, outcomes, and predictors of mortality, Jessica Parsh, Milan Seth, Jacqueline Green, Nadia R. Sutton, Stanley Chetcuti, Simon Dixon, Paul M. Grossman, Akshay Khandelwal, James M. Dupree, and Hitinder S. Gurm

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Tying Ourselves in Knots to Avoid Ventricular Pacing in Sick Sinus Syndrome: Does it Matter?, Claudio Schuger and Gurjit Singh

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Intentional Percutaneous Laceration of the Anterior Mitral Leaflet to Prevent Outflow Obstruction During Transcatheter Mitral Valve Replacement: First-in-Human Experience, Vasilis C. Babaliaros, Adam B. Greenbaum, Jaffar M. Khan, Toby Rogers, Dee Dee Wang, Marvin H. Eng, William O'Neill, Gaetano Paone, Vinod H. Thourani, Stamatios Lerakis, Dennis W. Kim, Marcus Y. Chen, and Robert J. Lederman

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Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation, Nancy Luo, Peter Merrill, Kishan S. Parikh, David J. Whellan, Ileana L. Piña, Mona Fiuzat, William E. Kraus, Dalane W. Kitzman, Steven J. Keteyian, Christopher M. O'Connor, and Robert J. Mentz

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Expert consensus document: Mitochondrial function as a therapeutic target in heart failure, David A. Brown, Justin B. Perry, Mitchell E. Allen, Hani N. Sabbah, Brian L. Stauffer, Saame R. Shaikh, John GF Cleland, Wilson S. Colucci, Javed Butler, Adriaan A. Voors, Stefan D. Anker, Bertram Pitt, Burkert Pieske, Gerasimos Filippatos, Stephen J. Greene, and Mihai Gheorghiade

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Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations, Javed Butler, Carine E. Hamo, James E. Udelson, Christopher O'Connor, Hani N. Sabbah, Marco Metra, Sanjiv J. Shah, Dalane W. Kitzman, John R. Teerlink, Harold S. Bernstein, Gabriel Brooks, Christophe Depre, Mary M. DeSouza, Wilfried Dinh, Mark Donovan, Regina Frische-Danielson, Robert J. Frost, Dahlia Garza, Udo-Michael Gohring, Jennifer Hellawell, Judith Hsia, Shiro Ishihara, Patricia Kay-Mugford, Joerg Koglin, Marc Kozinn, Christopher J. Larson, Martha Mayo, Li-Ming Gan, Pierrre Mugnier, Sekayi Mushonga, Lothar Roessig, Cesare Russo, Afshin Salsali, Carol Satler, Victor Shi, Barry Ticho, Michael van der Laan, Clyde Yancy, Norman Stockbridge, and Mihai Gheorghiade

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Predictors of Excess Patient Radiation Exposure During Chronic Total Occlusion Coronary Intervention: Insights From a Contemporary Multicentre Registry, Georgios E. Christakopoulos, Georgios Christopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W. Yeh, Farouc A. Jaffer, Michael R. Wyman, William L. Lombardi, Muhammad Nauman J Tarar, J A. Grantham, David E. Kandzari, Nicholas Lembo, Jeffrey W. Moses, Ajay J. Kirtane, Manish Parikh, Philip Green, Matthew Finn, Santiago Garcia, Anthony H. Doing, Raja Hatem, Craig A. Thompson, Subhash Banerjee, and Emmanouil S. Brilakis

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The Impact of Age and Sex on In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention, Aris Karatasakis, Rahel Iwnetu, Barbara A. Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A. Jaffer, Robert W. Yeh, David E. Kandzari, Nicholas J. Lembo, Mitul Patel, Ehtisham Mahmud, William L. Lombardi, R M. Wyman, J A. Grantham, Anthony H. Doing, Catalin Toma, James W. Choi, Barry F. Uretsky, Jeffrey W. Moses, Ajay J. Kirtane, Ziad A. Ali, Manish Parikh, Judit Karacsonyi, Bavana V. Rangan, Craig A. Thompson, Subhash Banerjee, and Emmanouil S. Brilakis

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Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions: insights from a US multicentre registry, J R. Martinez-Parachini, A Karatasakis, D Karmpaliotis, Khaldoon Alaswad, F A. Jaffer, R W. Yeh, M Patel, J Bahadorani, A Doing, P K. Nguyen-Trong, B A. Danek, J Karacsonyi, A Alame, B V. Rangan, C A. Thompson, S Banerjee, and E S. Brilakis

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Silent disease progression in clinically stable heart failure, Hani N. Sabbah

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Feasibility of Early Mechanical Support During Mechanical Reperfusion of Acute Myocardial Infarct Cardiogenic Shock, William O'Neill, Mir B. Basir, Simon Dixon, Kirit Patel, Theodore Schreiber, and Steven Almany

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Effect of Early Initiation of Mechanical Circulatory Support on Survival in Cardiogenic Shock, Mir B. Basir, Theodore L. Schreiber, Cindy L. Grines, Simon R. Dixon, Jeffrey W. Moses, Brijeshwar S. Maini, Akshay Khandelwal, Erik M. Ohman, and William O'Neill

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Surgical Paravalvular Leak Closure: No More Second Chances, Adam B. Greenbaum and Tiberio M. Frisoli

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Higher Fitness Is Strongly Protective in Patients with Family History of Heart Disease: The FIT Project, Mahmoud Al Rifai, Jaideep Patel, Rupert K. Hung, Khurram Nasir, Steven J. Keteyian, Clinton Brawner, Jonathan K. Ehrman, Sherif Sakr, Roger S. Blumenthal, Michael J. Blaha, and Mouaz H. Al-Mallah

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Change in Maximal Exercise Capacity Is Associated With Survival in Men and Women, Clinton Brawner, Mouaz H. Al-Mallah, Jonathan K. Ehrman, Waqas T. Qureshi, Michael J. Blaha, and Steven J. Keteyian

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Association Between Phase 3 Cardiac Rehabilitation and Clinical Events, Clinton Brawner, Daniel Girdano, Jonathan K. Ehrman, and Steven J. Keteyian

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Improved 5-year prediction of all-cause mortality by coronary CT angiography applying the CONFIRM score, Simon Deseive, Leslee J. Shaw, James K. Min, Stephan Achenbach, Daniele Andreini, Mouaz H. Al-Mallah, Daniel S. Berman, Matthew J. Budoff, Tracy Q. Callister, Filippo Cademartiri, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin JW Chow, Ricardo C. Cury, Augustin DeLago, Allison M. Dunning, Gudrun Feuchtner, Philipp Kaufmann, Yong-Jin Kim, Jonathon Leipsic, Hugo Marques, Erica Maffei, Gianluca Pontone, Gilbert Raff, Ronin Rubinshtein, Todd C. Villines, Jörg Hausleiter, and Martin Hadamitzky