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Submissions from 2020

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The deleterious role of the prostaglandin E2 EP3 receptor in angiotensin II hypertension, Timothy D. Bryson, Teja S. Pandrangi, Safa Z. Khan, Jiang Xu, Tengis S. Pavlov, Pablo A. Ortiz, Edward L. Peterson, and Pamela Harding

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Aldehyde dehydrogenase 2 inhibition potentiates 4-hydroxy-2-nonenal induced decrease in angiogenesis of coronary endothelial cells., Bipradas Roy and Suresh S. Palaniyandi

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Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics., Alexander Yang and Emilio P. Mottillo

Submissions from 2019

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cGMP Induces Degradation of NKCC2 in the Thick Ascending Limb via the Ubiquitin-Proteasomal System., Gustavo R. Ares

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Fructose acutely stimulates NKCC2 activity in rat thick ascending limbs by increasing surface NKCC2 expression., Gustavo R. Ares, Kamal M. Kassem, and Pablo A. Ortiz

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ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity., Sergey N. Arkhipov and Tengis S. Pavlov

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Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD, Sergey N. Arkhipov, D'Anna Potter, Aron M. Geurts, and Tengis S. Pavlov

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Delivering on the promise to improve the care of patients with pulmonary hypertension., Rana Awdish MD FCCP

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Prostaglandin E2 and an EP4 receptor agonist inhibit LPS-Induced monocyte chemotactic protein 5 production and secretion in mouse cardiac fibroblasts via Akt and NF-kappaB signaling, Timothy D. Bryson, Jacob Ross, Edward L. Peterson, and Pamela Harding

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Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in Gout., David Bursill, William J. Taylor, Robert Terkeltaub, Masanari Kuwabara, Tony R. Merriman, Rebecca Grainger, Carlos Pineda, Worawit Louthrenoo, N L. Edwards, Mariano Andrés, Ana B. Vargas-Santos, Edward Roddy, Tristan Pascart, Ching-Tsai Lin, Fernando Perez-Ruiz, Sara K. Tedeschi, Seoyoung C. Kim, Leslie R. Harrold, Geraldine McCarthy, Nitin Kumar, Peter T. Chapman, Anne-Kathrin Tausche, Janitzia Vazquez-Mellado, Marwin Gutierrez, Geraldo da Rocha Castelar-Pinheiro, Pascal Richette, Eliseo Pascual, Mark C. Fisher, Ruben Burgos-Vargas, Philip C. Robinson, Jasvinder A. Singh, Tim L. Jansen, Kenneth G Saag, Ole Slot, Tillmann Uhlig, Daniel H Solomon, Robert T Keenan, Carlo Alberto Scire, Edyta Biernat-Kaluza, Mats Dehlin, George Nuki, Naomi Schlesinger, Matthijs Janssen, Lisa K Stamp, Francisca Sivera, Anthony M Reginato, Lennart Jacobsson, Frédéric Lioté, Hang-Korng Ea, Ann Rosenthal, Thomas Bardin, Hyon K Choi, Michael S Hershfield, Christine Czegley, Sung Jae Choi, and Nicola Dalbeth

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Molecular Regulation of NKCC2 in Blood Pressure Control and Hypertension, Paulo S. Caceres and Pablo A. Ortiz

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Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats., Flavia M. Cerniello, Mauro G. Silva, Oscar A. Carretero, and Mariela M. Gironacci

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Urinary concentrating defect in mice lacking Epac1 or Epac2., Alena Cherezova, Viktor Tomilin, Vadym Buncha, Oleg Zaika, Pablo A. Ortiz, Fang Mei, Xiaodong Cheng, Mykola Mamenko, and Oleh Pochynyuk

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Urinary concentrating defect in mice lacking Epac1 or Epac2., Alena Cherezova, Viktor Tomilin, Vadym Buncha, Oleg Zaika, Pablo A. Ortiz, Fang Mei, Xiaodong Cheng, Mykola Mamenko, and Oleh Pochynyuk

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Superoxide increases surface NKCC2 in the rat thick ascending limbs via PKC., Mohammed Z. Haque and Pablo A. Ortiz

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Interleukin 4: Its Role in Hypertension, Atherosclerosis, Valvular, and Nonvalvular Cardiovascular Diseases., Kamal M. Kassem, Mahboob Ali, and Nour-Eddine Rhaleb

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Thymosinβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?, Kamal M. Kassem, Sonal Vaid, Hongmei Peng, Sarah Sarkar, and Nour-Eddine Rhaleb

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Increased ENaC activity during kidney preservation in Wisconsin solution., Sherif Khedr, Oleg Palygin, Tengis S. Pavlov, Gregory Blass, Vladislav Levchenko, Ammar Alsheikh, Michael W. Brands, Ashraf El-Meanawy, and Alexander Staruschenko

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Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure., Jasmine Luzum, Christopher Ting, Edward L. Peterson, Hongsheng Gui, Tyler Shugg, Keoki L. Williams, Liang Li, Wolfgang Sadee, Danxin Wang, and David E. Lanfear

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Genetically-encoded sensors to detect fatty acid production and trafficking, Emilio P. Mottillo

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Aldehyde Dehydrogenase (ALDH) 2 in Diabetic Heart Diseases., Srikar Munukutla, Guodong Pan, and Suresh S. Palaniyandi

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Blood Pressure Screening Campaign in Jamaica: May Measurement Month 2017., Magdalene Nwokocha, Cesar A. Romero, Cheryl Holder, Natalie Whylie, Hiu Wong, Joan Lietch, Rohan Wilks, Mark Hosang, Sheena Francis, Paul D. Brown, Tomlin Paul, Wendel Abel, Everard Barton, Rainford Wilks, and Chukwuemeka Nwokocha

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AC-SDKP treatment protects heart against excessive myocardial injury and heart failure in mice, Hongmei Peng, Jiang Xu, Xiao-Ping Yang, Kamal M. Kassem, Imane A. Rhaleb, Edward L. Peterson, and Nour-Eddine Rhaleb

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Tubule-vascular feedback in renal autoregulation., Cesar A. Romero and Oscar A. Carretero

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Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney., Cesar A. Romero, Nitin Kumar, Pablo Nakagawa, Morel E. Worou, Tang-Dong Liao, Edward L. Peterson, and Oscar A. Carretero

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Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney., Cesar A. Romero, Nitin Kumar, Pablo Nakagawa, Morel E. Worou, Tang-Dong Liao, Edward L. Peterson, and Oscar A. Carretero

Submissions from 2018

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beta1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells, Pei-Yin Ho, Hui Li, Tengis S. Pavlov, Roland D. Tuerk, Diego Tabares, René Brunisholz, Dietbert Neumann, Alexander Staruschenko, and Kenneth R. Hallows

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A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease., Daria V. Ilatovskaya, Gregory Blass, Oleg Palygin, Vladislav Levchenko, Tengis S. Pavlov, Michael N. Grzybowski, Kristen Winsor, Leonid S. Shuyskiy, Aron M. Geurts, Allen W. Cowley, Lutz Birnbaumer, and Alexander Staruschenko

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Role of Alström syndrome 1 in the regulation of blood pressure and renal function., Ankita B. Jaykumar, Paulo S. Caceres, Keyona N. King-Medina, Tang-Dong Liao, Indrani Datta, Dipak Maskey, Jürgen K. Naggert, Mariela Mendez, William H. Beierwaltes, and Pablo A. Ortiz

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Single-molecule labeling for studying trafficking of renal transporters., Ankita B. Jaykumar, Paulo S. Caceres, and Pablo A. Ortiz

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Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats., Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, Vijayasree V. Giridharan, Ashrith Guha, Arvind Bhimaraj, Keith A. Youker, Suresh S. Palaniyandi, Harry Karmouty-Quintana, Fadia Kamal, Kara L. Spiller, Kenichi Watanabe, and Rajarajan A. Thandavarayan

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Thymosin β4 Deficiency Exacerbates Renal and Cardiac Injury in Angiotensin-II-Induced Hypertension., Nitin Kumar, Tang-Dong Liao, Cesar A. Romero, Mani Maheshwari, Edward L. Peterson, and Oscar A. Carretero

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Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet., Mani Maheshwari, Cesar A. Romero, Sumit R. Monu, Nitin Kumar, Tang-Dong Liao, Edward L. Peterson, and Oscar A. Carretero

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Role of connecting tubule glomerular feedback in obesity related renal damage., Sumit R. Monu, Mani Maheshwari, Edward L. Peterson, and Oscar A. Carretero

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Connecting tubule glomerular feedback mediates tubuloglomerular feedback resetting after unilateral nephrectomy., Sumit R. Monu, Yilin Ren, J X. Masjoan-Juncos, Kristopher Kutskill, Hong Wang, Nitin Kumar, Edward L. Peterson, and Oscar A. Carretero

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Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction., Pablo Nakagawa, Cesar A. Romero, Xu Jiang, Martin D'Ambrosio, Ginette Bordcoch, Edward L. Peterson, Pamela Harding, Xiao-Ping Yang, and Oscar A. Carretero

Characterization of purinergic receptor expression in ARPKD cystic epithelia., Oleg Palygin, Daria V. Ilatovskaya, Vladislav Levchenko, Christine A. Klemens, Lashodya Dissanayake, Annaarie Williams, Tengis S. Pavlov, and Alexander Staruschenko

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Precision medicine approach: Empagliflozin for diabetic cardiomyopathy in mice with aldehyde dehydrogenase (ALDH) 2 * 2 mutation, a specific genetic mutation in millions of East Asians., Guodong Pan, Mandar Deshpande, Haiyan Pang, and Suresh S. Palaniyandi

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Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography., Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph D. Gardinier, Rajarajan A. Thandavarayan, and Suresh S. Palaniyandi

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Noninvasive measurement of renal blood flow by magnetic resonance imaging in rats., Cesar A. Romero, Glauber Cabral, Robert A. Knight, Guangliang Ding, Edward L. Peterson, and Oscar A. Carretero

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Free radical scavenging reverses fructose-induced salt-sensitive hypertension., Zachary P. Zenner, Kevin L. Gordish, and William H. Beierwaltes

Submissions from 2017

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MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a β-Arrestin2-Dependent Pathway., Flavia M. Cerniello, Oscar A. Carretero, Nadia A. Longo Carbajosa, Bruno D. Cerrato, Robson A. Santos, Hernán E. Grecco, and Mariela M. Gironacci

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MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke., Jieli Chen, Chengcheng Cui, Xiao-Ping Yang, Jiang Xu, Poornima Venkat, Alex Zacharek, Peng Yu, and Michael Chopp

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The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging., Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Sahana S. Babu, Suresh S. Palaniyandi, Kenichi Watanabe, John P. Cooke, and Rajarajan A. Thandavarayan

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Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy., Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Vijayasree V. Giridharan, Remya Sreedhar, Rajendran JC Bose, Jyothi Vanama, Suresh S. Palaniyandi, Tetsuya Konishi, Kenichi Watanabe, and Rajarajan A. Thandavarayan

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Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats., Tengis S. Pavlov, Vladislav Levchenko, Daria V. Ilatovskaya, Hui Li, Oleg Palygin, Nuria M. Pastor-Soler, Kenneth R. Hallows, and Alexander Staruschenko

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Effect of salt intake on afferent arteriolar dilatation: role of connecting tubule glomerular feedback (CTGF)., Hong Wang, Cesar A. Romero, J X. Masjoan Juncos, Sumit R. Monu, Edward L. Peterson, and Oscar A. Carretero

Submissions from 2016

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Heteromerization Between the Bradykinin B2 Receptor and the Angiotensin-(1-7) Mas Receptor: Functional Consequences., Bruno D. Cerrato, Oscar A. Carretero, Brana Janic, Hernán E. Grecco, and Mariela M. Gironacci

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Increased 4-hydroxy-2-nonenal-induced proteasome dysfunction is correlated with cardiac damage in streptozotocin-injected rats with isoproterenol infusion., Mandar Deshpande, Vishal R. Mali, Guodong Pan, Jiang Xu, Xiao-Ping Yang, Rajarajan A. Thandavarayan, and Suresh S. Palaniyandi

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Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension., Germán E. González, Nour-Eddine Rhaleb, Martin A. D'Ambrosio, Pablo Nakagawa, Tang-Dong Liao, Edward L. Peterson, Pablo Leung, Xiangguo Dai, Brana Janic, Yun-He Liu, Xiao-Ping Yang, and Oscar A. Carretero

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Angiotensin II stimulates superoxide production by nitric oxide synthase in thick ascending limbs., Agustin Gonzalez-Vicente, Jagannath H. Saikumar, Katherine J. Massey, Nancy J. Hong, Fernando P. Dominici, Oscar A. Carretero, and Jeffrey L. Garvin

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Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor., Xiaosong Gu, Jiang Xu, Liping Zhu, Timothy Bryson, Xiao-Ping Yang, Edward L. Peterson, and Pamela Harding

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Real-time monitoring of NKCC2 endocytosis by total internal reflection fluorescence (TIRF) microscopy., Ankita B. Jaykumar, Paulo S. Caceres, Ibrahim M. Sablaban, Bakhos A. Tannous, and Pablo A. Ortiz

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Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice., Vengadeshprabhu Karuppagounder, Vijayasree V. Giridharan, Somasundaram Arumugam, Remya Sreedhar, Suresh S. Palaniyandi, Prasanna Krishnamurthy, Joao Quevedo, Kenichi Watanabe, Tetsuya Konishi, and Rajarajan A. Thandavarayan

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Residues in the Distal Heme Pocket of Arabidopsis Non-Symbiotic Hemoglobins: Implication for Nitrite Reductase Activity., Nitin Kumar, Alessandra Astegno, Jian Chen, Alejandro Giorgetti, and Paola Dominici

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The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase., Nitin Kumar, Pablo Nakagawa, Brana Janic, Cesar A. Romero, Morel E. Worou, Sumit R. Monu, Edward L. Peterson, Jiajiu Shaw, Frederick A. Valeriote, Elimelda M. Ongeri, Jean-Marie V. Niyitegeka, Nour-Eddine Rhaleb, and Oscar A. Carretero

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Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes., Vishal R. Mali, Mandar Deshpande, Guodong Pan, Rajarajan A. Thandavarayan, and Suresh S. Palaniyandi

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Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity., Vishal R. Mali, Guodong Pan, Mandar Deshpande, Rajarajan A. Thandavarayan, Jiang Xu, Xiao-Ping Yang, and Suresh S. Palaniyandi

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Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?, Srikar Munukutla, Guodong Pan, Mandar Deshpande, Rajarajan A. Thandavarayan, Prasanna Krishnamurthy, and Suresh S. Palaniyandi

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K+-Mediated Regulation of Distal Convoluted Tubule Na/Cl Cotransporter Phosphorylation During Angiotensin II-Induced Hypertension., Pablo A. Ortiz

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ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes., Guodong Pan, Mandar Deshpande, Rajarajan A. Thandavarayan, and Suresh S. Palaniyandi

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Angiotensin II-mediated hypertension impairs nitric oxide-induced NKCC2 inhibition in thick ascending limbs., Vanesa D. Ramseyer, Pablo A. Ortiz, Oscar A. Carretero, and Jeffrey L. Garvin

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Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone., Yilin Ren, Brana Janic, Kristopher Kutskill, Edward L. Peterson, and Oscar A. Carretero

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Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice., Remya Sreedhar, Vijayasree V. Giridharan, Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Suresh S. Palaniyandi, Prasanna Krishnamurthy, Joao Quevedo, Kenichi Watanabe, Tetsuya Konishi, and Rajarajan A. Thandavarayan

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High salt diet and caffeine: food for thought., Alexander Staruschenko, Daria V. Ilatovskaya, and Tengis S. Pavlov

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Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation., Liping Zhu, Xiao-Ping Yang, Brana Janic, Nour-Eddine Rhaleb, Pamela Harding, Pablo Nakagawa, Edward L. Peterson, and Oscar A. Carretero

Submissions from 2015

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Direct renal effects of a fructose-enriched diet: interaction with high salt intake., Gustavo R. Ares and Pablo A. Ortiz

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Concentration-independent MRI of pH with a dendrimer-based pH-responsive nanoprobe., Mohammed PI Bhuiyan, Madhava P. Aryal, Brana Janic, Kishor Karki, Nadimpalli RS Varma, James R. Ewing, Ali S. Arbab, and Meser M. Ali

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Sca-1+ cells from fetal heart with high aldehyde dehydrogenase activity exhibit enhanced gene expression for self-renewal, proliferation, and survival., Devaveena Dey, Guodong Pan, Nadimpalli RS Varma, and Suresh S. Palaniyandi

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Inverse Correlation Between Plasma Adropin and ET-1 Levels in Essential Hypertension: A Cross-Sectional Study., Xiaosong Gu, Hui Li, Xinyi Zhu, Haibo Gu, Jianchang Chen, Luchen Wang, Pamela Harding, and Weiting Xu

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N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus., Tang-Dong Liao, Pablo Nakagawa, Brana Janic, Martin D'Ambrosio, Morel E. Worou, Edward L. Peterson, Nour-Eddine Rhaleb, Xiao-Ping Yang, and Oscar A. Carretero

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Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction., Hongmei Peng, Zeyd Sarwar, Xiao-Ping Yang, Edward L. Peterson, Jiang Xu, Brana Janic, Nadia Rhaleb, Oscar A. Carretero, and Nour-Eddine Rhaleb

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Renal protective effect of N-acetyl-seryl-aspartyl-lysyl-proline in dahl salt-sensitive rats., Morel E. Worou, Tang-Dong Liao, Martin D'Ambrosio, Pablo Nakagawa, Brana Janic, Edward L. Peterson, Nour-Eddine Rhaleb, and Oscar A. Carretero

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Activation of angiotensin II type 2 receptor suppresses TNF-α-induced ICAM-1 via NF-кB: possible role of ACE2., Liping Zhu, Oscar A. Carretero, Jiang Xu, Pamela Harding, Nithya Ramadurai, Xiaosong Gu, Edward L. Peterson, and Xiao-Ping Yang