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Submissions from 2021

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Developing a Professionalism and Harassment Policy for Organized Neurosurgery, Ellen L. Air, Katie O. Orrico, Deborah L. Benzil, Alan M. Scarrow, James R. Bean, Catherine A. Mazzola, Linda M. Liau, James T. Rutka, and Karin M. Muraszko

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Launching the Quality Outcomes Database Tumor Registry: rationale, development, and pilot data, Anthony L. Asher, Adham M. Khalafallah, Debraj Mukherjee, Mohammed Ali Alvi, Yagiz U. Yolcu, Inamullah Khan, Jacquelyn S. Pennings, Claudia A. Davidson, Kristin R. Archer, Yaron A. Moshel, John Knightly, Marie Roguski, Brad E. Zacharia, Robert E. Harbaugh, Steven N. Kalkanis, and Mohamad Bydon

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Reducing Superfluous Opioid Prescribing Practices After Brain Surgery: It Is Time to Talk About Drugs, Karam Asmaro, Hassan A. Fadel, Sameah A. Haider, Jacob Pawloski, Edvin Telemi, Tarek Mansour, Ankush Chandra, Michael Bazydlo, Adam M. Robin, Ian Y. Lee, Ellen L. Air, Jack P. Rock, Steven N. Kalkanis, and Jason M. Schwalb

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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine, Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. de Carvalho, Roel G.W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, and Florian L. Muller

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Laser interstitial thermotherapy (LITT) for the treatment of tumors of the brain and spine: a brief review, Clark Chen, Ian Lee, Claudio Tatsui, Theresa Elder, and Andrew E. Sloan

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CORM-2 inhibits intracerebral hemorrhage-mediated inflammation, Zhiying Chen, Huiyan Zhang, Jun Zhou, Christopher Stone, Yuchuan Ding, Yunzhou Zhang, Changhong Ren, Xiaoping Yin, and Ran Meng

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Age as a Predictor for Complications and Patient-reported Outcomes in Multilevel Transforaminal Lumbar Interbody Fusions: Analyses From the Michigan Spine Surgery Improvement Collaborative (MSSIC), Chad F. Claus, Doris Tong, Evan Lytle, Matthew Bahoura, Lucas Garmo, Chenxi Li, Paul Park, Daniel A. Carr, Richard Easton, Muwaffak M. Abdulhak, Victor Chang, Clifford Houseman, Peter Bono, Boyd Richards, and Teck M. Soo

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Expected Costs of Primary Dental Treatments and Endoscopic Sinus Surgery for Odontogenic Sinusitis, John R. Craig, Roderick W. Tataryn, Haley C. Sibley, William D. Mason, Joshua A. Deuel, Gary E. Loyd, David R. Nerenz, and Parul Goyal

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Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis, Indrani Datta, Houtan Noushmehr, Chaya Brodie, and Laila M. Poisson

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Systematic review on the use of patient-reported outcome measures in brain tumor studies: part of the Response Assessment in Neuro-Oncology Patient-Reported Outcome (RANO-PRO) initiative, Linda Dirven, Maartje E. Vos, Tobias Walbert, Terri S. Armstrong, David Arons, Martin J. van den Bent, Jaishri Blakeley, Paul D. Brown, Helen Bulbeck, Susan M. Chang, Corneel Coens, Mark R. Gilbert, Robin Grant, Rakesh Jalali, Danielle Leach, Heather Leeper, Tito Mendoza, Lakshmi Nayak, Kathy Oliver, Jaap C. Reijneveld, Emilie Le Rhun, Larry Rubinstein, Michael Weller, Patrick Y. Wen, and Martin J.B. Taphoorn

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Gender diversity in United States neurosurgery training programs, Katelyn Donaldson, Katherine E. Callahan, Aaron Gelinne, Wyll Everett, S. Elizabeth Ames, Ellen L. Air, and Susan R. Durham

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Minimally Invasive Techniques for Iliac Bolt Placement: 2-Dimensional Operative Video, Travis Hamilton, Mohamed Macki, Thomas M. Zervos, and Victor Chang

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Harmonized outcome measures for use in degenerative lumbar spondylolisthesis patient registries and clinical practice, Robert E. Harbaugh, Clinton Devin, Michelle B. Leavy, Zoher Ghogawala, Kristin R. Archer, Mohamad Bydon, Christine Goertz, Doron Dinstein, David R. Nerenz, Guy S. Eakin, William Lavelle, William O. Shaffer, Paul M. Arnold, Charles H. Washabaugh, and Richard E. Gliklich

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Decompression of Lumbar Central Spinal Canal Stenosis Following Minimally Invasive Transforaminal Lumbar Interbody Fusion, Jawad M. Khalifeh, Lara W. Massie, Christopher F. Dibble, Ian G. Dorward, Mohamed Macki, Umang Khandpur, Kafa Alshohatee, Deeptee Jain, Victor Chang, and Wilson Z. Ray

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Work relative value units and perioperative outcomes in patients undergoing brain tumor surgery, Robert B. Kim, Jonathan P. Scoville, Michael Karsy, Seokchun Lim, Randy L. Jensen, and Sarah T. Menacho

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Age as a Risk Factor for Complications Following Anterior Cervical Discectomy and Fusion: Analysis From the Michigan Spine Surgery Improvement Collaborative (MSSIC), Michael H. Lawless, Doris Tong, Chad F. Claus, Connor Hanson, Chenxi Li, Clifford M. Houseman, Peter Bono, Boyd F. Richards, Prashant S. Kelkar, Muwaffak M. Abdulhak, Victor Chang, Daniel A. Carr, Paul Park, and Teck M. Soo

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Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic stroke treatment with tPA, Chao Li, Chunyang Wang, Yi Zhang, Owais K. Alsrouji, Alex B. Chebl, Guangliang Ding, Quan Jiang, Stephan A. Mayer, Mei Lu, Max K. Kole, Horia L. Marin, Li Zhang, Michael Chopp, and Zhenggang Zhang

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Commentary: Complications Associated with Oblique Lumbar Interbody Fusion at L5-S1: A Systematic Review of the Literature, Seokchun Lim and Victor Chang

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Commentary: Impact of Opioid Prescribing Guidelines on Postoperative Opioid Prescriptions Following Elective Spine Surgery: Results From an Institutional Quality Improvement Initiative, Seokchun Lim and Victor Chang

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Commentary: Single-Position Surgery: Prone Lateral Lumbar Interbody Fusion: 2-Dimensional Operative Video, Seokchun Lim and Victor Chang

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Commentary: Lumbar Laminoplasty for Resection of Myxopapillary Ependymoma of the Conus Medullaris: 2-Dimensional Operative Video, Seokchun Lim, Mokbel Chedid, and Victor Chang

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Preoperative HbA1c > 8% Is Associated With Poor Outcomes in Lumbar Spine Surgery: A Michigan Spine Surgery Improvement Collaborative Study, Seokchun Lim, Hsueh-Han Yeh, Mohamed Macki, Tarek Mansour, Lonni Schultz, Edvin Telemi, Sameah A. Haider, David R. Nerenz, Jason M. Schwalb, Muwaffak M. Abdulhak, Paul Park, Ilyas Aleem, Richard Easton, Jad Khalil, Miguelangelo Perez-Cruet, and Victor Chang

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Minimally Invasive Posterior Cervical Discectomy: 2-Dimensional Operative Video, Seokchun Lim, Thomas M. Zervos, Travis Hamilton, and Victor Chang

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Analysis of Factors associated with Return to Work After Lumbar Surgery up to 2-years follow-up: A Michigan Spine Surgery Improvement Collaborative (MSSIC) Study, Mohamed Macki, Sharath K. Anand, Travis Hamilton, Seokchun Lim, Tarek Mansour, Michael Bazydlo, Lonni Schultz, Muwaffak M. Abdulhak, Jad G. Khalil, Paul Park, Ilyas Aleem, Richard Easton, Jason M. Schwalb, David R. Nerenz, and Victor Chang

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Commentary: Comparison of the Safety of Prophylactic Anticoagulants After Intracranial Surgery, Mohamed Macki and Victor Chang

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Prophylactic Low-Molecular-Weight Heparin Versus Unfractionated Heparin in Spine Surgery (PLUSS): A Pilot Matched Cohort Study, Mohamed Macki, Yazeed W. Haddad, Raviteja Suryadevara, Abed Latif Dabaja, Mokbel Chedid, and Victor Chang

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Expandable Cage Technology-Transforaminal, Anterior, and Lateral Lumbar Interbody Fusion, Mohamed Macki, Travis Hamilton, Yazeed W. Haddad, and Victor Chang

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The role of postoperative antibiotic duration on surgical site infection after lumbar surgery, Mohamed Macki, Travis Hamilton, Seokchun Lim, Tarek R. Mansour, Edvin Telemi, Michael Bazydlo, Lonni Schultz, David R. Nerenz, Paul Park, Victor Chang, Jason M. Schwalb, and Muwaffak M. Abdulhak

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Disparities in outcomes after spine surgery: a Michigan Spine Surgery Improvement Collaborative study, Mohamed Macki, Travis Hamilton, Seokchun Lim, Edvin Telemi, Michael Bazydlo, David R. Nerenz, Hesham M. Zakaria, Lonni Schultz, Jad G. Khalil, Miguelangelo J. Perez-Cruet, Ilyas S. Aleem, Paul Park, Jason M. Schwalb, Muwaffak M. Abdulhak, and Victor Chang

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The Effect of Antithrombotics on Hematoma Expansion in Small- to Moderate-Sized Traumatic Intraparenchymal Hemorrhages, Mohamed Macki, Jacob Pawloski, Hassan Fadel, Travis Hamilton, Sameah A. Haider, Jaafar Elmenini, Mohamed Fakih, Jeffrey L. johnson, and Jack Rock

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Fluorescence-Guided High-Grade Glioma Surgery More Than Four Hours After 5-Aminolevulinic Acid Administration, Georgios A. Maragkos, Alexander J. Schüpper, Nikita Lakomkin, Panagiotis Sideras, Gabrielle Price, Rebecca Baron, Travis Hamilton, Sameah A. Haider, Ian Lee, Constantinos G. Hadjipanayis, and Adam Robin

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A multisociety organizational consensus process to define guiding principles for acute perioperative pain management, Edward R. Mariano, David M. Dickerson, Joseph W. Szokol, Michael Harned, Jeffrey T. Mueller, Beverly K. Philip, Jaime L. Baratta, Padma Gulur, Jennifer Robles, Kristopher M. Schroeder, Karla E.K. Wyatt, Jason M. Schwalb, Eric S. Schwenk, Richa Wardhan, Todd S. Kim, Kent K. Higdon, Deepak G. Krishnan, Ashley M Shilling, Gary Schwartz, Lisa Wiechmann, Lisa V. Doan, Nabil M. Elkassabany, Stephen C. Yang, Iyabo O. Muse, Jean D. Eloy, Vikas Mehta, Shalini Shah, Rebecca L. Johnson, Michael J. Englesbe, Amanda Kallen, S. Bobby Mukkamala, Ashley Walton, and Asokumar Buvanendran

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Relationship between initial opioid prescription size and likelihood of refill after spine surgery, Lara Massie, Vidhya Gunaseelan, Jennifer Waljee, Chad Brummett, and Jason M. Schwalb

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Magnetic resonance-guided focused ultrasound treatment for essential tremor shows sustained efficacy: a meta-analysis, William K. Miller, Kathryn N. Becker, Andrew J. Caras, Tarek R. Mansour, Malik T. Mays, Mehmood Rashid, and Jason M. Schwalb

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Repeated Mechanical Endovascular Thrombectomy for Recurrent Large Vessel Occlusion: A Multicenter Experience, Ghada A. Mohamed, Hassan Aboul Nour, Raul G. Nogueira, Mahmoud H. Mohammaden, Diogo C. Haussen, Alhamza R. Al-Bayati, Thanh N. Nguyen, Mohamad Abdalkader, Artem Kaliaev, Alice Ma, Johanna Fifi, Jacob Morey, Dileep R. Yavagal, Vasu Saini, Santiago Ortega-Gutierrez, Mudassir Farooqui, Cynthia B. Zevallos, Darko Quispe-Orozco, Lonni Schultz, Max Kole, Daniel J. Miller, Stephan A. Mayer, Horia Marin, and Alex B. Chebl

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DNA Methylation-based Signatures Classify Sporadic Pituitary Tumors According to Clinicopathological Features, Maritza S. Mosella, Thais S. Sabedot, Tiago C. Silva, Tathiane M. Malta, Felipe D Segato, Karam P. Asmaro, Michael Wells, Abir Mukherjee, Laila M. Poisson, James Snyder, Ana C. de Carvalho, Tobias Walbert, Todd Aho, Steven N. Kalkanis, Paula C. Elias, Sonir R. Antonini, Jack Rock, Houtan Noushmehr, Margaret Castro, and Ana V. Castro

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The minimally invasive interbody selection algorithm for spinal deformity, Praveen V. Mummaneni, Ibrahim Hussain, Christopher I. Shaffrey, Robert K. Eastlack, Gregory M. Mundis, Juan S. Uribe, Richard G. Fessler, Paul Park, Leslie Robinson, Joshua Rivera, Dean Chou, Adam S. Kanter, David O. Okonkwo, Pierce D. Nunley, Michael Y. Wang, Frank LaMarca, Khoi D. Than, and Kai-Ming Fu

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Real-World Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A Multicenter Retrospective Observational Study, Yasunori Nagahama, Thomas M. Zervos, Kristina K. Murata, Lynette Holman, Torin Karsonovich, Jonathon J. Parker, Jia-Shu Chen, H. Westley Phillips, Marytery Fajardo, Hiroki Nariai, Shaun A. Hussain, Brenda E. Porter, Gerald A. Grant, John Ragheb, Shelly Wang, Brent R. O'Neill, Allyson L. Alexander, Robert J. Bollo, and Aria Fallah

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Adaptation of laser interstitial thermal therapy for tumor ablation under MRI monitoring in a rat orthotopic model of glioblastoma, Tavarekere N. Nagaraja, Seamus Bartlett, Katelynn G. Farmer, Glauber Cabral, Robert A. Knight, Olivia Valadie, Stephen L. Brown, James R. Ewing, and Ian Y. Lee

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Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma, Tavarekere N. Nagaraja, Rasha Elmghirbi, Stephen L. Brown, Julian A. Rey, Lonni Schultz, Abir Mukherjee, Glauber Cabral, Swayamprava Panda, Ian Y. Lee, Malisa Sarntinoranont, Kelly A. Keenan, Robert A. Knight, and James R. Ewing

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Cerebral microcirculation in glioblastoma: A major determinant of diagnosis, resection, and drug delivery, Tavarekere N. Nagaraja and Ian Y. Lee

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Genomic Biomarkers of Meningioma: A Focused Review, Jacob A. Pawloski, Hassan A. Fadel, Yi-Wen Huang, and Ian Y. Lee

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Sensitive Detection of Thiourea Hazardous Toxin with Sandwich-Type Nafion/CuO/ZnO Nanospikes/Glassy Carbon Composite Electrodes, Mohammed M. Rahman, Md M. Alam, Sulaiman Y.M. Alfaifi, Abdullah M. Asiri, and Meser M. Ali

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Predicting master transcription factors from pan-cancer expression data, Jessica Reddy, Marcos A.S. Fonseca, Rosario I. Corona, Robbin Nameki, Felipe Segato Dezem, Isaac A. Klein, Heidi Chang, Daniele Chaves-Moreira, Lena K. Afeyan, Tathiane M. Malta, Xianzhi Lin, Forough Abbasi, Alba Font-Tello, Thais Sabedot, Paloma Cejas, Norma Rodríguez-Malavé, Ji-Heui Seo, De-Chen Lin, Ursula Matulonis, Beth Y. Karlan, Simon A. Gayther, Bogdan Pasaniuc, Alexander Gusev, Houtan Noushmehr, Henry Long, Matthew L. Freedman, Ronny Drapkin, Richard A. Young, Brian J. Abraham, and Kate Lawrenson

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A serum-based DNA methylation assay provides accurate detection of glioma, Thais S. Sabedot, Tathiane Malta, James Snyder, Kevin K. Nelson, Michael Wells, Ana C. de Carvalho, Abir Mukherjee, Dhananjay A. Chitale, Maritza Mosella, Artem Sokolov, Karam Asmaro, Adam Robin, Michael Rosenblum, Tom Mikkelsen, Jack Rock, Laila M. Poisson, Ian Lee, Tobias Walbert, Steven N. Kalkanis, Antonio Iavarone, Ana V. Castro, and Houtan Noushmehr

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A Neurosurgical Community Under Attack, Philippe Schucht, Jack Rock, Kee B. Park, Yoko Kato, Russell J. Andrews, Isabelle M. Germano, and Franco Servadei

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5-Aminolevulinic acid for enhanced surgical visualization of high-grade gliomas: a prospective, multicenter study, Alexander J. Schupper, Rebecca B. Baron, William Cheung, Jessica Rodriguez, Steven N. Kalkanis, Muhammad O. Chohan, Bruce J. Andersen, Roukoz Chamoun, Brian V. Nahed, Brad E. Zacharia, Jerone Kennedy, Hugh D. Moulding, Lloyd Zucker, Michael R. Chicoine, Jeffrey J. Olson, Randy L. Jensen, Jonathan H. Sherman, Xiangnan Zhang, Gabrielle Price, Mary Fowkes, Isabelle M. Germano, Bob S. Carter, Constantinos G. Hadjipanayis, and Raymund L. Yong

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North American survey on impact of the COVID-19 pandemic shutdown on DBS care, Mustafa S. Siddiqui, Joohi Jimenez-Shahed, Zoltan Mari, Benjamin L. Walter, Sol De Jesus, Fedor Panov, Jason M. Schwalb, Michele K. York, Harini Sarva, John M. Bertoni, Neepa Patel, Lin Zhang, James McInerney, and Joshua M. Rosenow

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Quantification of pial collateral pressure in acute large vessel occlusion stroke: basic concept with patient outcomes, Rizwan A. Tahir, Muhammad Affan, Horia Marin, Sameah A. Haider, Owais K. Alsrouji, Ayesha Ahmad, Alex B. Chebl, Angelos Katramados, Meredith Van Harn, and Max Kole

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Prognostic significance of genome-wide DNA methylation profiles within the randomised, phase 3, EORTC CATNON trial on non-1p/19q deleted anaplastic glioma, C. M.S. Tesileanu, M. J. van den Bent, M. Sanson, W. Wick, A. A. Brandes, P. M. Clement, S. C. Erridge, M. A. Vogelbaum, A. K. Nowak, J. F. Baurain, W. P. Mason, H. Wheeler, O. L. Chinot, S. Gill, M. Griffin, L. Rogers, W. Taal, R. Rudà, M. Weller, C. McBain, M. E. van Linde, Thais S. Sabedot, Y Hoogstrate, A von Deimling, I de Heer, W. F.J. van IJcken, R. W.W. Brouwer, K. Aldape, R. B. Jenkins, H. J. Dubbink, J. M. Kros, P. Wesseling, K. J. Cheung, V. Golfinopoulos, B. G. Baumert, T. Gorlia, H. Noushmehr, and P. J. French

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Neurosurgeons perspective on the shift towards earlier use of deep brain stimulation for Parkinson disease, Paola Testini, Harini Sarva, Jason M. Schwalb, Samantha Barkan, and Laura Y. Cabrera

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Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome, Irene Unterman, Idit Bloch, Simona Cazacu, Gila Kazimirsky, Bruria Ben-Zeev, Benjamin P. Berman, Chaya Brodie, and Yuval Tabach

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SNO and EANO practice guideline update: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors, Tobias Walbert, Rebecca A. Harrison, David Schiff, Edward K. Avila, Merry Chen, Padmaja Kandula, Jong Woo Lee, Emilie Le Rhun, Glen H.J. Stevens, Michael A. Vogelbaum, Wolfgang Wick, Michael Weller, Patrick Y. Wen, and Elizabeth R. Gerstner

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Association between Implementation of a Universal Face Mask Policy for Healthcare Workers in a Health Care System & SARS-CoV-2 positivity testing rate in Healthcare Workers, Dee Dee Wang, William O'Neill, Marcus J. Zervos, John E. McKinnon, David Allard, George J. Alangaden, Lonni R. Schultz, Laila M. Poisson, Betty S. Chu, Steven N. Kalkanis, and Geehan Suleyman

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Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas, Queenie Hoi-Wing Wong, Kay Ka-Wai Li, Wei-Wei Wang, Tathiane M. Malta, Houtan Noushmehr, Yura Grabovska, Chris Jones, Aden Ka-Yin Chan, Johnny Sheung-Him Kwan, Queenie Jun-Qi Huang, Gabriel Chun-Hei Wong, Wen-Cai Li, Xian-Zhi Liu, Hong Chen, Danny Tat-Ming Chan, Ying Mao, Zhen-Yu Zhang, Zhi-Feng Shi, and Ho-Keung Ng

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In Reply: Contemporary Analysis of Minimal Clinically Important Difference in the Neurosurgical Literature, Thomas M. Zervos, Karam Asmaro, and Ellen L. Air

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MiR-17-92 Cluster-Enriched Exosomes Derived from Human Bone Marrow Mesenchymal Stromal Cells Improve Tissue and Functional Recovery in Rats after Traumatic Brain Injury, Yanlu Zhang, Yi Zhang, Michael Chopp, Haiyan Pang, Zhenggang Zhang, Asim Mahmood, and Ye Xiong

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Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription, Yanfen Zhu, Amit D. Gujar, Chee-Hong Wong, Harianto Tjong, Chew Yee Ngan, Liang Gong, Yi-An Chen, Hoon Kim, Jihe Liu, Meihong Li, Adam Mil-Homens, Rahul Maurya, Chris Kuhlberg, Fanyue Sun, Eunhee Yi, Ana C. de Carvalho, Yijun Ruan, Roel G.W. Verhaak, and Chia-Lin Wei

Submissions from 2020

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Clinical Context-Aware Biomedical Text Summarization Using Deep Neural Network: Model Development and Validation, Muhammad Afzal, Fakhare Alam, Khalid Mahmood Malik, and Ghaus M. Malik

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M2 segment thrombectomy is not associated with increased complication risk compared to M1 segment: A meta-analysis of recent literature, Christopher Alexander, Andrew Caras, William K. Miller, Rizwan Tahir, Tarek Mansour, Azedine Medhkour, and Horia Marin

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What have we learned from C5 palsy - A short communication, Sharath Kumar Anand and Mohamed Macki

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Patient navigation in epilepsy care, Sharath Kumar Anand, Mohamed Macki, Lauren G. Culver, Vibhangini S. Wasade, Samantha Hendren, and Jason M. Schwalb

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Magnetic resonance-guided laser interstitial thermal therapy for posterior fossa neoplasms, Omar Ashraf, Grant Arzumanov, Evan Luther, J. Tanner McMahon, James G. Malcolm, Samuel Mansour, Ian Y. Lee, Jon T. Willie, Ricardo J. Komotar, and Shabbar F. Danish

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Expanded Endonasal Approach for Resection of Extradural Infratemporal Fossa Trigeminal Schwannoma: 2-Dimensional Operative Video, Karam Asmaro, Jack Rock, and John R. Craig

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Dynamic foraminal dimensions during neck motion 6.5 years after fusion and artificial disc replacement, Sherwin Azad, Daniel Oravec, Timothy Baumer, Andrew Schildcrout, Parnell White, Azam Basheer, Michael J. Bey, Stephen W. Bartol, Victor Chang, and Yener N. Yeni

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Minimally Invasive Surgery Strategies: Changing the Treatment of Spine Tumors, Ori Barzilai, Adam M. Robin, John E. O'Toole, and Ilya Laufer

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Toward an understanding of sexual harassment in neurosurgery, Deborah L. Benzil, Karin M. Muraszko, Pranay Soni, Ellen L. Air, Katie O. Orrico, and James T. Rutka

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Randomized prospective trial of fractionated stereotactic radiosurgery with chemotherapy versus chemotherapy alone for bevacizumab-resistant high-grade glioma, David Bergman, Ankit Modh, Lonni Schultz, James Snyder, Tom Mikkelsen, Mira M. Shah, Samuel Ryu, M Salim Siddiqui, and Tobias Walbert

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miR-504 modulates the stemness and mesenchymal transition of glioma stem cells and their interaction with microglia via delivery by extracellular vesicles, Ariel Bier, Xin Hong, Simona Cazacu, Hodaya Goldstein, Daniel Rand, Cunli Xiang, Wei Jiang, Hiba Waldman Ben-Asher, Moshe Attia, Aharon Brodie, Ruicong She, Laila M. Poisson, and Chaya Brodie

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Usefulness and Impact of Intraoperative Imaging for Glioma Resection on Patient Outcome and Extent of Resection: A Systematic Review and Meta-Analysis, Andrew Caras, Luke Mugge, William K. Miller, Tarek R. Mansour, Jason Schroeder, and Azedine Medhkour

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Machine Learning Applications in the Neuro ICU: A Solution to Big Data Mayhem?, Farhan Chaudhry, Rachel J. Hunt, Prashant Hariharan, Sharath Kumar Anand, Surya Sanjay, Ellen E. Kjoller, Connor M. Bartlett, Kipp W. Johnson, Phillip D. Levy, Houtan Noushmehr, and Ian Y. Lee

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Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling, Jian Chen, Abhisek Mitra, Shulin Li, Shumei Song, Bao-Ngoc Nguyen, Jiun-Sheng Chen, Ji-Hyun Shin, Nancy R. Gough, Paul Lin, Vincent Obias, Aiwu Ruth He, Zhixing Yao, Tathiane M. Malta, Houtan Noushmehr, Patricia S Latham, Xiaoping Su, Asif Rashid, Bibhuti Mishra, Ray-Chang Wu, and Lopa Mishra

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Frequency and Analysis of Unplanned Extubation in Coronavirus Disease 2019 Patients, Anoop K. Chhina, Gary E. Loyd, Trevor J. Szymanski, Katherine A. Nowak, William T. Peruzzi, Nicholas S. Yeldo, Xiaoxia Han, Lotfi S. Kerzabi, Dragos M. Galusca, Simona Cazacu, Chaya Brodie, and Donald H. Penning

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Effect of Vocimagene Amiretrorepvec in Combination With Flucytosine vs Standard of Care on Survival Following Tumor Resection in Patients With Recurrent High-Grade Glioma: A Randomized Clinical Trial, Timothy F. Cloughesy, Kevin Petrecca, Tobias Walbert, Nicholas Butowski, Michael Salacz, James Perry, Denise Damek, Daniela Bota, Chetan Bettegowda, Jay-Jiguang Zhu, Fabio Iwamoto, Dimitris Placantonakis, Lyndon Kim, Brad Elder, George Kaptain, David Cachia, Yaron Moshel, Steven Brem, David Piccioni, Joseph Landolfi, Clark C. Chen, Harry Gruber, Aliz R. Rao, Daniel Hogan, William Accomando, Derek Ostertag, Tiffany T. Montellano, Thian Kheoh, Fairooz Kabbinavar, and Michael A. Vogelbaum

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Interpreting pathways to discover cancer driver genes with Moonlight, Antonio Colaprico, Catharina Olsen, Matthew H. Bailey, Gabriel J. Odom, Thilde Terkelsen, Tiago C. Silva, André V. Olsen, Laura Cantini, Andrei Zinovyev, Emmanuel Barillot, Houtan Noushmehr, Gloria Bertoli, Isabella Castiglioni, Claudia Cava, Gianluca Bontempi, Xi S. Chen, and Elena Papaleo

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Transpars approach for L5-S1 foraminal and extra-foraminal lumbar disc herniations: technical note, Pasquale De Bonis, Antonio Musio, Lorenzo Mongardi, Giorgio Lofrese, Frank LaMarca, Jacopo Visani, Michele A. Cavallo, and Alba Scerrati

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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology, Anna Golebiewska, Ann-Christin Hau, Anaïs Oudin, Daniel Stieber, Yahaya A. Yabo, Virginie Baus, Vanessa Barthelemy, Eliane Klein, Sébastien Bougnaud, Olivier Keunen, May Wantz, Alessandro Michelucci, Virginie Neirinckx, Arnaud Muller, Tony Kaoma, Petr V. Nazarov, Francisco Azuaje, Alfonso De Falco, Ben Flies, Lorraine Richart, Suresh Poovathingal, Thais Arns, Kamil Grzyb, Andreas Mock, Christel Herold-Mende, Anne Steino, Dennis Brown, Patrick May, Hrvoje Miletic, Tathiane M. Malta, Houtan Noushmehr, Yong-Jun Kwon, Winnie Jahn, Barbara Klink, Georgette Tanner, Lucy F. Stead, Michel Mittelbronn, Alexander Skupin, Frank Hertel, Rolf Bjerkvig, and Simone P. Niclou

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Mutated CEACAMs Disrupt Transforming Growth Factor Beta Signaling and Alter the Intestinal Microbiome to Promote Colorectal Carcinogenesis, Shoujun Gu, Sobia Zaidi, Imtaiyaz Hassan, Taj Mohammad, Tathiane M. Malta, Houtan Noushmehr, Bryan Nguyen, Keith A. Crandall, Jigisha Srivastav, Vincent Obias, Paul Lin, Bao-Ngoc Nguyen, Michael Yao, Ren Yao, Charles H. King, Raja Mazumder, Bibhuti Mishra, Shuyun Rao, and Lopa Mishra

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The Economic Impact of Glioma Survivorship: the cost of care from a patient perspective, Sameah A. Haider, Karam Asmaro, Steven N. Kalkanis, Ian Y. Lee, Michael Bazydlo, David R. Nerenz, Ramzi G. Salloum, James Snyder, and Tobias Walbert

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Commentary: The Role of Stereotactic Radiosurgery in the Management of Brain Metastases From a Health-Economic Perspective: A Systematic Review, Sameah A. Haider, Christopher D. Shank, and Beverly C. Walters

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Catastrophic failure of spinal cord stimulator paddle electrodes in the cervical spine, Stacy E. Hatcher and Ellen L. Air

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The Future of Neurocritical Care Research: Proceedings and Recommendations from the Fifth Neurocritical Care Research Network Conference, S Hocker, S Shah, P Vespa, J J. Provencio, E Calvillo, D M. Olson, C P. Venkatasubba Rao, J C. Hemphill, R Helbok, T Human, H Kamel, L K. Madden, P Nyquist, O Bentho, K O'Phelan, J J. Lewin, S Alexander, W Ziai, S H. Chou, F Rincon, M McNett, N Ko, B Zink, D Rhoney, M N. Diringer, R Stevens, C S. Robertson, G Sampaio, L A. Shutter, G Ling, M Rehman, S H. Mahmoud, S Yeager, S Livesay, and J I. Suarez

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Education and evidence-based medicine in neurosurgery, Steven N. Kalkanis, Christopher I. Shaffrey, Ganesh Rao, Shelly D. Timmons, Brian L. Hoh, and John A. Wilson

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Optimizing eligibility criteria and clinical trial conduct to enhance clinical trial participation for primary brain tumor patients, Eudocia Q. Lee, Michael Weller, Joohee Sul, Stephen J. Bagley, Solmaz Sahebjam, Martin van den Bent, Manmeet Ahluwalia, Jian L. Campian, Evanthia Galanis, Mark R. Gilbert, Matthias Holdhoff, Glenn J. Lesser, Frank S. Lieberman, Minesh P. Mehta, Marta Penas-Prado, Karisa C. Schreck, Roy E. Strowd, Michael A. Vogelbaum, Tobias Walbert, Susan M. Chang, L B. Nabors, Stuart Grossman, David A. Reardon, and Patrick Y. Wen

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Training Neurosurgeons in Myanmar and Surrounding Countries: The Resident Perspective, Jacob R. Lepard, Jacquelyn Corley, Eric W. Sankey, Tyler Prentiss, Brandon Rocque, Kee B. Park, Jack Rock, Kyi Hlaing, and Win Myaing

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MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury, Lian Li, Michael Chopp, Guangliang Ding, Esmaeil Davoodi-Bojd, Li Zhang, Qingjiang Li, Yanlu Zhang, Ye Xiong, and Quan Jiang

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Remote Ischemic Conditioning Improves Attention Network Function and Blood Oxygen Levels in Unacclimatized Adults Exposed to High Altitude, Sijie Li, Cong Han, Karam Asmaro, Shanyi Quan, Ming Li, Changhong Ren, Jun Zhang, Wenbo Zhao, Jiali Xu, Zhiwen Liu, Peng Zhang, Lingling Zhu, Yuchuan Ding, Kai Wang, Xunming Ji, and Lian Duan

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Prevalence of Alternative Diagnoses and Implications for Management in Idiopathic Normal Pressure Hydrocephalus Patients, Mohamed Macki, Abhimanyu Mahajan, Rhonna Shatz, Ellen L. Air, Marina Novikova, Mohamed Fakih, Jaafar Elmenini, Manpreet Kaur, Kenneth R. Bouchard, Brent A. Funk, and Jason M. Schwalb

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Introducing the Rupture Criticality Index to Compare Risk Factor Combinations Associated with Aneurysmal Rupture, Khalid Mahmood Malik, Madan Krishnamurthy, Fakhare Alam, Hesham M. Zakaria, and Ghaus Malik

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Intraluminal Carotid Artery Thrombus in COVID-19: Another Danger of Cytokine Storm?, Ali Y. Mohamud, Brent Griffith, Mohammed Rehman, Daniel Miller, Alex B. Chebl, Suresh C. Patel, Bradley Howell, Max Kole, and Horia Marin

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TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas, Koushik Muralidharan, Anudeep Yekula, Julia L. Small, Zachary S. Rosh, Keiko M. Kang, Lan Wang, Spencer Lau, Hui Zheng, Hakho Lee, Chetan Bettegowda, Michael R. Chicoine, Steven N. Kalkanis, Ganesh M. Shankar, Brian V. Nahed, William T. Curry, Pamela S. Jones, Daniel P. Cahill, Leonora Balaj, and Bob S. Carter

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Rapid Multi-contrast Brain Imaging on a 035T MR-linac, Siamak P. Nejad-Davarani, Niloufar Zakariaei, Yongsheng Chen, E Mark Haacke, Newton J. Hurst, M Salim Siddiqui, Lonni R. Schultz, James M. Snyder, Tobias Walbert, and Carri K. Glide-Hurst

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Nitrous oxide-induced demyelination: Clinical presentation, diagnosis and treatment recommendations, Thomas Noh, Gamaleldin Osman, Mokbel Chedid, and Hebah Hefzy

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Impaired neurocognitive function in glioma patients: from pathophysiology to novel intervention strategies, Kyle R. Noll, Tobias Walbert, and Jeffrey S. Wefel

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Letter: COVID-19 Pandemic-The Bystander Effect on Stroke Care in Michigan, Aditya S. Pandey, Badih J. Daou, Jenny P. Tsai, Syed F. Zaidi, Hisham Salahuddin, Joseph J. Gemmete, Marion J. Oliver, Justin Singer, Theresa A. Elder, Nnenna Mbabuike, Joseph G. Adel, Yogesh Gujrati, Muhammad Adeel Saleemi, Fazeel M. Siddiqui, Augusto E. Elias, Mohammed F. Rehman, Horia Marin, Alex B. Chebl, Max Kole, Jeffrey M. Wilseck, Chris D. Kazmierczak, James M. Mick, Aniel Q. Majjhoo, Bharath R. Naravetla, Mahmoud Rayes, Ali W. Luqman, Boyd F. Richards, Prashant Kelkar, Richard Burgess, B Gregory Thompson, Neeraj Chaudhary, Paul A. Mazaris, Omar Qahwash, M Anmar Razak, and Mouhammad A. Jumaa

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Impact of Michigan's new opioid prescribing laws on spine surgery patients: analysis of the Michigan Spine Surgery Improvement Collaborative., Paul Park, Victor Chang, Hsueh-Han Yeh, Jason M. Schwalb, David R. Nerenz, Lonni R. Schultz, Muwaffak M. Abdulhak, Richard Easton, Miguelangelo Perez-Cruet, Osama N. Kashlan, Mark E. Oppenlander, Nicholas J. Szerlip, Kevin N. Swong, and Ilyas S. Aleem

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A Phase II and Pharmacodynamic Trial of RO4929097 for Patients With Recurrent/Progressive Glioblastoma, David M. Peereboom, Xiaobu Ye, Tom Mikkelsen, Glenn J. Lesser, Frank S. Lieberman, H. Ian Robins, Manmeet S. Ahluwalia, Andrew E. Sloan, and Stuart A. Grossman

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A Bayesian Adaptive Randomized Phase II Multicenter Trial of Bevacizumab with or without Vorinostat in Adults with Recurrent Glioblastoma, Vinay K. Puduvalli, Jing Wu, Ying Yuan, Terri S. Armstrong, Elizabeth Vera, Jimin Wu, Jihong Xu, Pierre Giglio, Howard Colman, Tobias Walbert, Jeffrey Raizer, Morris D. Groves, David Tran, Fabio Iwamoto, Nicholas Avgeropoulos, Nina Paleologos, Karen Fink, David Peereboom, Marc Chamberlain, Ryan Merrell, Marta Penas Prado, W KA Yung, and Mark R. Gilbert

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Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Neuroablative Procedures for Patients With Cancer Pain, Ahmed M. Raslan, Sharona Ben-Haim, Steven M. Falowski, André G. Machado, Jonathan Miller, Julie G. Pilitsis, William S. Rosenberg, Joshua M. Rosenow, Jennifer Sweet, Ashwin Viswanathan, Christopher J. Winfree, and Jason M. Schwalb

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Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of chemotherapeutic management and antiangiogenic treatment of newly diagnosed glioblastoma in adults, Navid Redjal, Brian V. Nahed, Jorg Dietrich, Steven N. Kalkanis, and Jeffrey J. Olson